CD22

Gene Symbol	CD22
Entrez Gene	933
Alt Symbol	SIGLEC-2, SIGLEC2
Species	Human
Gene Type	protein-coding
Description	CD22 molecule
Other Description	B-cell receptor CD22|B-lymphocyte cell adhesion molecule|BL-CAM|CD22 antigen|T-cell surface antigen Leu-14|sialic acid binding Ig-like lectin 2|sialic acid-binding Ig-like lectin 2
Swissprots	Q9UQA7 Q01665 Q32M46 F5GYU4 Q9Y2A6 O95699 P20273 Q9UQA6 O95702 O95703 F5H7U3 Q9UQB0 Q9UQA8 Q92872 Q92873 O95701 Q9UQA9
Accessions	AAB06448 AAB06449 AAC18956 ABK41939 BAA36564 BAA36565 BAA36566 BAA36567 BAA36568 BAA36569 BAA36570 BAA36571 BAA36572 BAA36573 BAA36574 BAA36575 BAA36576 BAF32756 BAF32757 BAF32758 CBH30554 P20273 AK026467 BAB15489 AK225625 AK225694 AK301177 BAH13422 BC109306 AAI09307 BC109307 BQ054599 CF138699 DA931592 DA989528 DB333800 X52785 CAA36988 X59350 CAA42006 NM_024916 NM_001185099 NP_001172028 NM_001185100 NP_001172029 NM_001185101 NP_001172030 NM_001278417 NP_001265346 NM_001771 NP_001762
Function	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	B-lymphocytes.
Top Pathways	Hematopoietic cell lineage, B cell receptor signaling pathway, Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD22-Over-expression-Lysate - LY12437a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CD22 overexpression lysate - LY434364 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

CD22 293 Cell Lysate - 409246 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

CD22 Over-expression Lysate Product - GWB-5C4F22 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Rhesus Siglec-2 / CD22 HEK293 Cell Lysate (WB positive control) - 90246-C08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Rhesus CD22 HEK293 Cell Lysate (WB positive control) - 90246-C02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human Siglec-2 / CD22 HEK293 Cell Lysate (WB positive control) - 11958-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Siglec-2 / CD22 (aa 176-687) HEK293 Cell Lysate (WB positive control) - 11958-H08H1L-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Siglec-2 / CD22 (ECD) HEK293 Cell Lysate (WB positive control) - 11958-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Siglec-2 Human Cells Transfected Lysate (positive control) (denatured) - orb173789 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human Siglec-2 (aa 176-687) Human Cells Transfected Lysate (positive control) (denatured) - orb175525 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human Siglec-2 Human Cells Transfected Lysate (positive control) (denatured) - orb232906 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human CD22 Knockdown Stable Cell Line - CSC-DC002719 from Creative biogene Category Cell Line Species Human

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