| Gene Symbol |
ZFP36
|
| Entrez Gene |
7538
|
| Alt Symbol |
G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ZFP36 ring finger protein
|
| Other Description |
G0/G1 switch regulatory protein 24|growth factor-inducible nuclear protein NUP475|tristetraprolin|tristetraproline|zinc finger protein 36 homolog|zinc finger protein 36, C3H type, homolog|zinc finger protein, C3H type, 36 homolog
|
| Swissprots |
P26651 B2RA54
|
| Accessions |
AAC37600 AAV28731 CBX47646 EAW56885 EAW56886 P26651 AJ227917 AK314042 BAG36751 BC009693 AAH09693 BM055332 EU446714 ABZ92243 EU832179 ACE87529 EU832272 ACE86842 M63625 AAA61240 M92843 AAA58489 NM_003407 NP_003398
|
| Function |
mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post- transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). {ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:23644599}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15014438}. Cytoplasm {ECO:0000269|PubMed:15014438}. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
|
| Top Pathways |
HTLV-I infection
|
![Western Blot: TTP Overexpression Lysate (Adult Normal) [NBL1-18018] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TTP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5143_TTP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-18018-img0002.jpg)