| Gene Symbol |
KCNMA1
|
| Entrez Gene |
3778
|
| Alt Symbol |
BKTM, KCa1.1, MaxiK, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, mSLO1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, calcium activated large conductance subfamily M alpha, member 1
|
| Other Description |
BK channel alpha subunit|BKCA alpha subunit|big potassium channel alpha subunit|calcium-activated potassium channel subunit alpha-1|calcium-activated potassium channel, subfamily M subunit alpha-1|hSlo|k(VCA)alpha|maxi-K channel HSLO|potassium large conductance calcium-activated channel, subfamily M, alpha member 1|slo homolog|slowpoke homolog|stretch-activated Kca channel
|
| Swissprots |
Q12791 Q5SQR9 Q9UBB0 Q96LG8 Q12960 Q12917 Q9UCX0 Q9UQK6 F8WA96 Q5JQ23 Q12886 Q13150 Q12921
|
| Accessions |
AAD21968 EAW54597 EAW54598 EAW54599 EAW54600 EAW54601 EAW54602 Q12791 AB113382 BAD06365 AB113575 BAD06397 AB209488 BAD92725 AB524033 BAJ07308 AF025999 AAB88802 AF118141 AAD31173 AF349445 AAK30158 AK024857 AK055362 AK098326 AK124355 AK128392 AK310379 AY040849 AAK91504 AY445624 AAS01054 BC009695 BC024965 BC062659 AAH62659 BC137115 AAI37116 BC137137 AAI37138 BC144496 AAI44497 BQ574058 BX648925 CR627384 CAH10480 U02632 AAA50173 U09384 AAA50216 U11058 AAB65837 U11717 AAC50353 U13913 AAA85104 U23767 AAA92290 XM_005269776 XP_005269833 XM_005269778 XP_005269835 XM_005269781 XP_005269838 XM_005269787 XP_005269844 XM_005269789 XP_005269846 XM_005269792 XP_005269849 XM_005269796 XP_005269853 XM_005269797 XP_005269854 XM_006717826 XP_006717889 XM_006717829 XP_006717892 XM_011539773 XP_011538075 XM_011539774 XP_011538076 XM_011539775 XP_011538077 XM_011539776 XP_011538078 XM_011539777 XP_011538079 XM_011539778 XP_011538080 XM_011539779 XP_011538081 XM_011539780 XP_011538082 XM_011539781 XP_011538083 XM_011539782 XP_011538084 XM_011539783 XP_011538085 XM_011539784 XP_011538086 XM_011539785 XP_011538087 NM_001014797 NP_001014797 NM_001161352 NP_001154824 NM_001161353 NP_001154825 NM_001271518 NP_001258447 NM_001271519 NP_001258448 NM_002247 NP_002238 NM_001271520 NP_001258449 NM_001271521 NP_001258450 NM_001271522 NP_001258451
|
| Function |
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phospho
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:20693285, ECO:0000269|PubMed:22399288}; Multi-pass membrane protein {ECO:0000269|PubMed:20693285, ECO:0000269|PubMed:22399288}.
|
| Tissue Specificity |
Widely expressed. Except in myocytes, it is almost ubiquitously expressed. {ECO:0000269|PubMed:11880513}.
|
| Top Pathways |
Vascular smooth muscle contraction, Salivary secretion, Pancreatic secretion, cGMP-PKG signaling pathway
|