Gene Symbol | GCNT2 |
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Entrez Gene | 2651 |
Alt Symbol | CCAT, CTRCT13, GCNT2C, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3, bA360O19.2, bA421M1.1 |
Species | Human |
Gene Type | protein-coding |
Description | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) |
Other Description | I beta-1,6-N-acetylglucosaminyltransferase|Ii blood group|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase|beta-1,6-N-acetylglucosaminyltransferase 2 |
Swissprots | Q6T5E5 Q8N0V5 Q5T4J1 Q8NFS9 Q06430 Q5W0E9 |
Accessions | AAA99832 EAW55259 EAW55260 EAW55261 EAW55262 Q06430 Q8N0V5 Q8NFS9 AB078432 BAC66781 AB078433 BAC66782 AF401652 AAL50561 AF401653 AAL50562 AF458024 AAM73864 AF458025 AAM73865 AF458026 AAM73866 AF458027 AAM73867 AF458028 AAM74524 AF458029 AAM73869 AF458030 AAM73870 AK090483 BAC03464 AK098105 BAC05234 AK291195 BAF83884 AK291767 BAF84456 AK307329 AK307337 AK307373 AK310216 AK313426 BAG36218 AK313903 BAG36626 AL832714 AL832719 AY435145 AAR95646 AY435146 AAR95647 AY435147 AAR95648 BC074801 AAH74801 BC074802 AAH74802 BC130524 AAI30525 BX503586 BX647576 CAI46081 BX647668 DB208581 HQ258240 ADR82994 L19659 AAA81777 Z19550 CAA79610 XM_005248997 XP_005249054 XM_005248999 XP_005249056 XM_006715052 XP_006715115 XM_006715053 XP_006715116 XM_011514465 XP_011512767 XM_011514466 XP_011512768 XM_011514467 XP_011512769 XM_011514468 XP_011512770 XR_926136 XR_926137 XR_926138 NM_001491 NP_001482 NM_145649 NP_663624 NM_145655 NP_663630 |
Function | Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | In the adult, highly expressed in prostate and to a lesser extent in small intestine and colon. Barely detected in heart, brain, kidney and pancreas. No expression in placenta, lung, liver, skeletal muscle, spleen, thymus, testis, ovary and peripheral blood leukocytes. In fetus, highly expressed in brain and to a lesser extent in lung and kidney. Barely detected in liver. {ECO:0000269|PubMed:12424189, ECO:0000269|PubMed:9405606}. |
Top Pathways | Glycosphingolipid biosynthesis - lacto and neolacto series |
GCNT2 (N-12) - sc-161625 from Santa Cruz Biotechnology
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Anti-GCNT2 antibody - ab107511 from Abcam
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Anti-GCNT2 antibody - ab121888 from Abcam
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Anti-GCNT2 antibody - ab69964 from Abcam
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Anti-GCNT2 antibody - ab103696 from Abcam
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Anti-GCNT2 antibody - ab174175 from Abcam
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Anti-GCNT2 Antibody (aa364-391, AP) - LS-C257620 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa364-391, APC) - LS-C257621 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa364-391, FITC) - LS-C257623 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa364-391, Biotin) - LS-C257622 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa213-240, AP) - LS-C257625 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa364-391, PE) - LS-C257626 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa364-391, Azide-free, HRP) - LS-C257624 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa213-240, APC) - LS-C257627 from LifeSpan Bioscience
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Anti-GCNT2 Antibody - LS-C307661 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa213-240, FITC) - LS-C257629 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa213-240, Azide-free, HRP) - LS-C257630 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa213-240, Biotin) - LS-C257628 from LifeSpan Bioscience
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Anti-GCNT2 Antibody - LS-C311171 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa213-240, PE) - LS-C257631 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa371-399) - LS-C321588 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa212-240) - LS-C321587 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa213-240) - LS-C159720 from LifeSpan Bioscience
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Anti-GCNT2 Antibody (aa364-391) - LS-C166415 from LifeSpan Bioscience
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GCNT2 Antibody - NBP1-88781 from Novus Biologicals
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