AKR1C4

Gene Symbol AKR1C4
Entrez Gene 1109
Alt Symbol 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member C4
Other Description 3-alpha-HSD1|aldo-keto reductase family 1 member C4|chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4|dihydrodiol dehydrogenase isozyme DD4|type I 3-alpha-hydroxysteroid dehydrogenase
Swissprots Q5T6A3 Q8WW84 Q9NS54 P17516
Accessions AAB47003 BAA92893 BAB43901 CBX51394 EAW86450 P17516 AB031085 BAA92885 AB045829 BAA99542 AK314988 BC020744 AAH20744 D26125 BAA05122 DQ891424 ABM82350 DQ894598 ABM85524 M33375 AAA35658 S68287 AAD14010 XM_011519303 XP_011517605 NM_001818 NP_001809
Function Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Subcellular Location Cytoplasm.
Tissue Specificity Liver specific. {ECO:0000269|PubMed:11158055, ECO:0000269|PubMed:7650035}.
Top Pathways Primary bile acid biosynthesis, Steroid hormone biosynthesis, Metabolism of xenobiotics by cytochrome P450

DD (C-12) - sc-166297 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DD (C-12): sc-166297. Western blot analysis of DD3 expression in non-transfected: sc-117752 (A) and human DD3 transfected: sc-158433 (B) 293T whole cell lysates.

DD (N-19) - sc-20425 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DD (N-19): sc-20425. Western blot analysis of DD expression in Hep G2 whole cell lysate (A) and mouse liver extract (B).

DD4 (F-16) - sc-27920 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DD4 (N-15) - sc-27919 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DD4 (WW3) - sc-100526 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
DD4 (WW3): sc-100526. Western blot analysis of DD4 expression in MCF7 whole cell lysate.

DD1-4 (H-78) - sc-292897 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DD1-4 (H-78): sc-292897. Western blot analysis of DD1-4 expression in Hep G2 (A) and A549 (B) whole cell lysates.

Anti-HSD3a antibody - ab197973 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HSD3a antibody (ab197973) at 1/400 dilution + mouse liver tissue lysate at 40 µg

Anti-HSD3a antibody - ab54606 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
HSD3a antibody (ab54606) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human liver tissue.

Anti-HSD3a antibody - ab50415 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-HSD3a antibody (ab50415) at 0.1 µg/ml + Human Liver lysate (35µg protein in RIPA buffer).

Anti-HSD3a antibody - ab96135 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-HSD3a antibody (ab96135) at 1/1000 dilution (10% SDS PAGE) + HeLa whole cell lysate at 30 µg

Anti-HSD3a antibody - ab151319 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HSD3a antibody (ab151319) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-HSD3a antibody [EPR8643(2)] - N-terminal - ab180590 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8643(2)
All lanes : Anti-HSD3a antibody [EPR8643(2)] - N-terminal (ab180590) at 1/10000 dilutionLane 1 : HepG2 cell line lysate at 20 µgLane 2 : MCF7 cell line lysate at 10 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-AKR1C4 / Chlordecone Reductase Antibody (aa10-39, APC) - LS-C212650 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1C4 / Chlordecone Reductase Antibody (aa10-39, Biotin) - LS-C212651 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1C4 / Chlordecone Reductase Antibody (aa10-39, AP) - LS-C212649 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1C4 / Chlordecone Reductase Antibody (aa10-39, FITC) - LS-C212652 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1C4 / Chlordecone Reductase Antibody (aa10-39, PE) - LS-C212654 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1C4 / Chlordecone Reductase Antibody - LS-C306189 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-AKR1C4 / Chlordecone Reductase Antibody - LS-C309396 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1C4 / Chlordecone Reductase Antibody (aa10-39, Azide-free, HRP) - LS-C212653 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1C4 / Chlordecone Reductase Antibody - LS-C309397 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AKR1C4 / Chlordecone Reductase Antibody (aa11-39) - LS-C156219 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
AKR1C4 Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The AKR1C4 antibody detected the AKR1C4 protein (arrow).

Anti-AKR1C4 / Chlordecone Reductase Antibody (aa10-39) - LS-C329210 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1C4 / Chlordecone Reductase Antibody (aa1-217) - LS-C185549 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded gastric ca using AKR1C4 antibody at 1:100 dilution.

Anti-AKR1C4 / Chlordecone Reductase Antibody - LS-C332462 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using AKR1C4 antibody.
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