| Gene Symbol | PLG |
|---|---|
| Entrez Gene | 733660 |
| Alt Symbol | - |
| Species | Pig |
| Gene Type | protein-coding |
| Description | plasminogen |
| Other Description | - |
| Swissprots | Q19AZ9 P06867 |
| Accessions | P06867 AK232298 AK232527 AK232883 AK346154 AK394190 DQ530369 ABF82358 XM_005659111 XP_005659168 NM_001044590 NP_001038055 |
| Function | Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted {ECO:0000250}. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface (By similarity). {ECO:0000250}. |
| Top Pathways | Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A, Neuroactive ligand-receptor interaction |
Plasminogen, Polyclonal Antibody - MBS2026927 from MyBioSource
|
||||||||
Plasminogen - ARB-65095 from Nordic BioSite
|