| Gene Symbol |
Anpep
|
| Entrez Gene |
16790
|
| Alt Symbol |
AP-M, AP-N, Apn, Cd13, P150
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
alanyl (membrane) aminopeptidase
|
| Other Description |
alanyl aminopeptidase|aminopeptidase M|aminopeptidase N|aminopeptidase N/CD13|membrane protein p161|microsomal aminopeptidase
|
| Swissprots |
Q91YH8 Q99K63 P97449
|
| Accessions |
EDL07044 P97449 AI848985 AK143746 BAE25523 AK171427 BAE42445 BC005431 AAH05431 BC017011 AAH17011 BC040792 AAH40792 U77083 AAB19065 XM_006540678 XP_006540741 NM_008486 NP_032512
|
| Function |
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May have a role in angiogenesis (By similarity). Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells. {ECO:0000250, ECO:0000269|PubMed:8103749}.
|
| Subcellular Location |
Membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Highly expressed in intestinal tract and kidney, present in liver, lymph node, spleen, and brain. Found as well in monocytes, macrophages, dendritic cells, veiled cells and B-cells but not on T-cells and thymocytes. {ECO:0000269|PubMed:8805662}.
|
| Top Pathways |
Hematopoietic cell lineage, Glutathione metabolism, Renin-angiotensin system
|