PLEKHH2

Gene Symbol PLEKHH2
Entrez Gene 130271
Alt Symbol PLEKHH1L
Species Human
Gene Type protein-coding
Description pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
Other Description pleckstrin homology domain-containing family H member 2
Swissprots Q8N3Q3 Q5JPJ6 Q8IVE3 Q6P4Q1
Accessions Q8IVE3 AB095948 BAC23124 AK124381 AK126308 AL832207 CAI46132 AL833400 CAD38637 AL833473 AL833546 AM392539 CAL37417 BC031914 BC063310 AAH63310 XM_011532539 XP_011530841 XR_244924 XR_426981 XR_939656 XR_939657 NM_172069 NP_742066
Function In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:22832517}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22832517}. Cell membrane {ECO:0000269|PubMed:22832517}; Peripheral membrane protein {ECO:0000269|PubMed:22832517}; Cytoplasmic side {ECO:0000269|PubMed:22832517}. Cell projection, lamellipodium {ECO:0000269|PubMed:22832517}. Note=Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K.
Tissue Specificity Kidney. Reduced expression in patients with focal segmental glomerulosclerosis. {ECO:0000269|PubMed:22832517}.

PLEKHH2 CRISPR/Cas9 KO Plasmid (h) - sc-414361 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHH2 HDR Plasmid (h) - sc-414361-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHH2 Double Nickase Plasmid (h) - sc-414361-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHH2 Double Nickase Plasmid (h2) - sc-414361-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHH2 CRISPR Activation Plasmid (h) - sc-414361-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHH2 CRISPR Activation Plasmid (h2) - sc-414361-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHH2 Lentiviral Activation Particles (h) - sc-414361-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHH2 Lentiviral Activation Particles (h2) - sc-414361-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHH2 siRNA (h) - sc-94672 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLEKHH2 shRNA Plasmid (h) - sc-94672-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLEKHH2 shRNA (h) Lentiviral Particles - sc-94672-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU046051 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16968 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11410 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11410

PLEKHH2 siRNA (Human) - CRJ5025 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human PLEKHH2 siRNA - orb275526 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PLEKHH2 shRNA Plasmid (Human) - CHJ5025 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PLEKHH2 miRNA 3'UTR clone - MiUTR4H-TG06774 from Creative biogene

Species Reactivities Human
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