Gene Symbol | Ngf |
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Entrez Gene | 18049 |
Alt Symbol | Ngfb |
Species | Mouse |
Gene Type | protein-coding |
Description | nerve growth factor |
Other Description | beta-NGF|beta-nerve growth factor|nerve growth factor, beta |
Swissprots | Q6LDB7 Q63864 P01139 |
Accessions | AAA37686 AAA37687 EDL07614 EDL07615 P01139 AK144588 BAE25950 BC011123 BC156604 AAI56605 BF786523 BY334442 K01759 AAA39820 M14805 AAA39821 M35075 AAA39818 S62089 AAB26820 V00836 CAA24221 XM_006501108 XP_006501171 XM_006501109 XP_006501172 XM_006501110 XP_006501173 NM_001112698 NP_001106168 NM_013609 NP_038637 |
Function | Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. {ECO:0000250|UniProtKB:P01138}. |
Subcellular Location | Secreted. |
Top Pathways | Apoptosis, MAPK signaling pathway, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Inflammatory mediator regulation of TRP channels |
NGF CRISPR/Cas9 KO Plasmid (m) - sc-421889 from Santa Cruz Biotechnology
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NGF HDR Plasmid (m) - sc-421889-HDR from Santa Cruz Biotechnology
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NGF Double Nickase Plasmid (m) - sc-421889-NIC from Santa Cruz Biotechnology
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NGF Double Nickase Plasmid (m2) - sc-421889-NIC-2 from Santa Cruz Biotechnology
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NGF CRISPR Activation Plasmid (m) - sc-421889-ACT from Santa Cruz Biotechnology
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NGF CRISPR Activation Plasmid (m2) - sc-421889-ACT-2 from Santa Cruz Biotechnology
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NGF Lentiviral Activation Particles (m) - sc-421889-LAC from Santa Cruz Biotechnology
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NGF Lentiviral Activation Particles (m2) - sc-421889-LAC-2 from Santa Cruz Biotechnology
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NGF siRNA (m) - sc-45783 from Santa Cruz Biotechnology
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NGF shRNA Plasmid (m) - sc-45783-SH from Santa Cruz Biotechnology
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NGF shRNA (m) Lentiviral Particles - sc-45783-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU025831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN36425 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36425 from Sigma-Aldrich
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NGF siRNA (Mouse) - CRM2769 from Cohesion Biosciences
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shRNA set against Mouse NGF (NM_013609.2) - SHH352120 from Creative biogene
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Mouse NGF siRNA - orb282245 from Biorbyt
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NGF shRNA Plasmid (Mouse) - CHM2769 from Cohesion Biosciences
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NGF miRNA 3'UTR clone - MiUTR1M-07646 from Creative biogene
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