Gene Symbol | ATP6V0D1 |
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Entrez Gene | 9114 |
Alt Symbol | ATP6D, ATP6DV, P39, VATX, VMA6, VPATPD |
Species | Human |
Gene Type | protein-coding |
Description | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 |
Other Description | 32 kDa accessory protein|ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D|H(+)-transporting two-sector ATPase, subunit D|V-ATPase 40 KDa accessory protein|V-ATPase AC39 subunit|V-ATPase subunit d 1|V-ATPase, subunit D|V-type proton ATPase subunit d 1|vacuolar proton pump subunit d 1 |
Swissprots | Q02547 P12953 P61421 |
Accessions | EAW83135 EAW83136 P61421 AK125522 AK128641 AK300570 BAH13305 AK301630 BAH13524 AK313035 BAG35868 BC008861 AAH08861 BI552108 BM677562 DQ893270 ABM84196 DQ896601 ABM87600 L05087 AAC15852 X71490 CAA50591 XM_011523444 XP_011521746 XM_011523445 XP_011521747 XM_011523446 XP_011521748 XM_011523447 XP_011521749 NM_004691 NP_004682 |
Function | Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305|PubMed:21844891}; Peripheral membrane protein {ECO:0000305|PubMed:21844891}; Cytoplasmic side {ECO:0000305|PubMed:21844891}. Note=Localizes to centrosome and the base of the cilium. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:12384298, ECO:0000269|PubMed:8250920}. |
Top Pathways | Lysosome, Collecting duct acid secretion, Phagosome, Rheumatoid arthritis, Synaptic vesicle cycle |
V-ATPase D1 CRISPR/Cas9 KO Plasmid (h) - sc-403669 from Santa Cruz Biotechnology
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V-ATPase D1 HDR Plasmid (h) - sc-403669-HDR from Santa Cruz Biotechnology
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V-ATPase D1 Double Nickase Plasmid (h) - sc-403669-NIC from Santa Cruz Biotechnology
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V-ATPase D1 Double Nickase Plasmid (h2) - sc-403669-NIC-2 from Santa Cruz Biotechnology
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V-ATPase D1 CRISPR Activation Plasmid (h) - sc-403669-ACT from Santa Cruz Biotechnology
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V-ATPase D1 CRISPR Activation Plasmid (h2) - sc-403669-ACT-2 from Santa Cruz Biotechnology
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V-ATPase D1 Lentiviral Activation Particles (h) - sc-403669-LAC from Santa Cruz Biotechnology
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V-ATPase D1 Lentiviral Activation Particles (h2) - sc-403669-LAC-2 from Santa Cruz Biotechnology
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V-ATPase D1 siRNA (h) - sc-63207 from Santa Cruz Biotechnology
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V-ATPase D1 shRNA Plasmid (h) - sc-63207-SH from Santa Cruz Biotechnology
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V-ATPase D1 shRNA (h) Lentiviral Particles - sc-63207-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU017111 from Sigma-Aldrich
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MISSION® esiRNA - EHU126061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3722 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3722 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04696 from Sigma-Aldrich
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ATP6V0D1 siRNA (Human) - CRH6023 from Cohesion Biosciences
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ATP6V0D1 RNAi - H00009114-R02 from Novus Biologicals
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ATP6V0D1 - MBS8218389 from MyBioSource
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shRNA set against Human ATP6V0D1 (NM_004691.4) - SHH243038 from Creative biogene
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shRNA set against Human ATP6V0D1(NM_004691.4) - SHG083521 from Creative biogene
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Human ATP6V0D1 siRNA - orb266525 from Biorbyt
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ATP6V0D1 shRNA Plasmid (Human) - CHH6023 from Cohesion Biosciences
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ATP6V0D1 miRNA 3'UTR clone - MiUTR1H-00711 from Creative biogene
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