APH1B

Gene Symbol APH1B
Entrez Gene 83464
Alt Symbol APH-1B, PRO1328, PSFL, TAAV688
Species Human
Gene Type protein-coding
Description APH1B gamma secretase subunit
Other Description anterior pharynx defective 1 homolog B|aph-1beta|gamma-secretase subunit APH-1B
Swissprots Q9H0S0 A8K589 Q8WW43 Q564N3 Q6UWQ1
Accessions EAW77644 EAW77645 Q8WW43 AA808355 AB189172 BAD95573 AB197122 BAE02660 AF508794 AAN63817 AI693802 AK057677 AK291204 BAF83893 AK307456 AK307725 AK310843 AL136671 CAB66606 AM392724 CAL37602 AM392878 CAL37756 AY358698 AAQ89061 BC020905 AAH20905 BI825203 DA397427 DQ891401 ABM82327 XM_011522105 XP_011520407 NM_001145646 NP_001139118 NM_031301 NP_112591
Function Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. {ECO:0000269|PubMed:12297508}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12740439}.
Top Pathways Notch signaling pathway, Alzheimer's disease

Aph-1b CRISPR/Cas9 KO Plasmid (h) - sc-413474 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Aph-1b HDR Plasmid (h) - sc-413474-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Aph-1b Double Nickase Plasmid (h) - sc-413474-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Aph-1b Double Nickase Plasmid (h2) - sc-413474-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Aph-1b CRISPR Activation Plasmid (h) - sc-413474-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Aph-1b CRISPR Activation Plasmid (h2) - sc-413474-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Aph-1b Lentiviral Activation Particles (h) - sc-413474-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Aph-1b Lentiviral Activation Particles (h2) - sc-413474-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Aph-1b siRNA (h) - sc-60190 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Aph-1b shRNA Plasmid (h) - sc-60190-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Aph-1b shRNA (h) Lentiviral Particles - sc-60190-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU019631 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3317 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3317 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

APH1B siRNA (Human) - CRJ3110 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

APH1B - MBS8218321 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human APH1B (NM_031301.3) - SHH238210 from Creative biogene

Category siRNA
Species Reactivities Human

APH1B shRNA Plasmid (Human) - CHJ3110 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

APH1B miRNA 3'UTR clone - MiUTR4H-TG00402 from Creative biogene

Species Reactivities Human
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