EXOSC7

Gene Symbol EXOSC7
Entrez Gene 23016
Alt Symbol EAP1, RRP42, Rrp42p, hRrp42p, p8
Species Human
Gene Type protein-coding
Description exosome component 7
Other Description exosome complex component RRP42|exosome complex exonuclease RRP42|ribosomal RNA-processing protein 42
Swissprots Q96E72 Q15024
Accessions EAW64731 EAW64732 EAW64733 EAW64734 Q15024 AK090511 AK130053 AK295779 BAG58602 AK315741 BAG38096 BC012831 AAH12831 BU153856 D29958 BAA06226 XR_245104 XR_940394 NM_015004 NP_055819 NR_023353
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
Top Pathways RNA degradation

EXOSC7 CRISPR/Cas9 KO Plasmid (h) - sc-405734 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC7 HDR Plasmid (h) - sc-405734-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC7 Double Nickase Plasmid (h) - sc-405734-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC7 Double Nickase Plasmid (h2) - sc-405734-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC7 CRISPR Activation Plasmid (h) - sc-405734-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC7 CRISPR Activation Plasmid (h2) - sc-405734-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC7 Lentiviral Activation Particles (h) - sc-405734-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC7 Lentiviral Activation Particles (h2) - sc-405734-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXOSC7 siRNA (h) - sc-77294 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EXOSC7 shRNA Plasmid (h) - sc-77294-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EXOSC7 shRNA (h) Lentiviral Particles - sc-77294-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Exosome component 7 RNAi - H00023016-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU160171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8052 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8052 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

EXOSC7 siRNA (Human) - CRH7932 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EXOSC7 - MBS8226561 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EXOSC7 (NM_015004.3) - SHH288153 from Creative biogene

Category siRNA
Species Reactivities Human

Human EXOSC7 siRNA - orb268434 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EXOSC7 shRNA Plasmid (Human) - CHH7932 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EXOSC7 miRNA 3'UTR clone - MiUTR3H-08499 from Creative biogene

Species Reactivities Human
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