FGFR4

Gene Symbol	FGFR4
Entrez Gene	2264
Alt Symbol	CD334, JTK2, TKF
Species	Human
Gene Type	protein-coding
Description	fibroblast growth factor receptor 4
Other Description	hydroxyaryl-protein kinase|protein-tyrosine kinase|tyrosine kinase related to fibroblast growth factor receptor|tyrosylprotein kinase
Swissprots	P22455 Q96KE5 Q71TW8 O43785 Q8TDA0 G3JVM9 G3JVM2 G3JVM7 G3JVM5 Q14309
Accessions	AAB25788 AAM13666 ABQ01235 CAA74200 CAB75718 EAW85034 EAW85035 EAW85036 EAW85037 P22455 AB209631 BAD92868 AF202063 AAF27432 AF359241 AAK43714 AF359246 AAK51435 AK225280 AK225909 AK301169 BAG62757 BC011847 AAH11847 BF307233 BM453707 DQ893458 ABM84384 DQ896348 ABM87347 EU826602 ACF47638 EU826603 ACF47639 JN007471 AEO19712 JN007472 AEO19713 JN007473 AEO19714 JN007474 AEO19715 JN007475 AEO19716 JN007476 AEO19717 JN007477 AEO19718 JN007478 AEO19719 JN007479 AEO19720 JN007480 AEO19721 JN007481 AEO19722 JN007482 AEO19723 L03840 AAB59389 M59373 AAA63208 X57205 CAA40490 XM_005265838 XP_005265895 XM_011534464 XP_011532766 XM_011534465 XP_011532767 XR_941090 NM_001291980 NP_001278909 NM_002011 NP_002002 NM_022963 NP_075252 NM_213647 NP_998812
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is
Subcellular Location	Isoform 3: Cytoplasm {ECO:0000269|PubMed:11781352}.
Tissue Specificity	Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. {ECO:0000269|PubMed:10631118}.
Top Pathways	MAPK signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® FGF Receptor 4 Kinase Assay Kit - 7737 from Cell Signaling Technology Category Assay Kit

Human FGFR4 ELISA Kit (Sandwich ELISA) - LS-F6633 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.064 ng/ml Range 0.156-10 ng/ml

Human Total FGF R4 DuoSet IC ELISA - DYC685-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 156.00 - 10,000 pg/mL

Human Total FGF R4 DuoSet IC, 5 Plate - DYC685-5 from R&D Systems Category ELISA Kit

Human Phospho-FGF R4 DuoSet IC ELISA - DYC5516-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 15.60 - 1,000 pg/mL

Human Phospho-FGF R4 DuoSet IC, 5 Plate - DYC5516-5 from R&D Systems Category ELISA Kit

Human FGFR4 ELISA Kit - abx151533 from Abbexa Category ELISA Kit Sensitivity 0.041 ng/ml Range 0.156 ng/ml - 10 ng/ml

Fibroblast Growth Factor Receptor 4, FGFR4, Human, ELISA Kit - E-EL-H0357 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Fibroblast growth factor receptor 4 (FGFR4), Human, ELISA Kit - CSB-EL008648HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.78 ng/ml Range 3.12 ng/ml-200 ng/ml

Fibroblast Growth Factor Receptor 4 (FGFR4), Human, ELISA Kit - SEB799Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.041 ng/mL Range 0.156-10 ng/mL

Fibroblast Growth Factor Receptor 4, FGFR4, Rabbit, ELISA Kit - E-EL-RB2135 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Fibroblast Growth Factor Receptor 4, FGFR4, Chicken, ELISA Kit - E-EL-Ch0510 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Fibroblast Growth Factor Receptor 4, FGFR4, Porcine, ELISA Kit - E-EL-P0715 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Fibroblast Growth Factor Receptor 4, FGFR4, Sheep, ELISA Kit - E-EL-S0205 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Fibroblast Growth Factor Receptor 4, FGFR4, Guinea Pig, ELISA Kit - E-EL-GP0322 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Fibroblast Growth Factor Receptor 4, FGFR4, Monkey, ELISA Kit - E-EL-MK0902 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human FGFR4(Fibroblast Growth Factor Receptor 4) ELISA Kit - E-EL-H0357 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human FGFR4 (Fibroblast Growth Factor Receptor 4) CLIA Kit - E-CL-H0289 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

FGFR4, ELISA Kit - MBS2505278 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

FGFR4, ELISA Kit - MBS2504313 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

FGFR4, ELISA Kit - MBS2512257 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

FGFR4, ELISA Kit - MBS2505893 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

FGFR4, ELISA Kit - MBS2507730 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

FGFR4, ELISA Kit - MBS2512100 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

FGFR4, ELISA Kit - MBS2505966 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human FGFR4 is 0.094ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.156-10ng/mL

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