Gene Symbol | MAPRE1 |
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Entrez Gene | 22919 |
Alt Symbol | EB1 |
Species | Human |
Gene Type | protein-coding |
Description | microtubule-associated protein, RP/EB family, member 1 |
Other Description | APC-binding protein EB1|adenomatous polyposis coli-binding protein EB1|end-binding protein 1|microtubule-associated protein RP/EB family member 1 |
Swissprots | E1P5M8 B2R6I7 Q15691 Q3KQS8 |
Accessions | EAW76348 EAW76349 Q15691 AK297273 BAG59745 AK310817 AK312590 BAG35484 BC040410 BC106068 AAI06069 BC109281 AAI09282 BC128442 AAI28443 BJ992159 BM983860 EU832776 ACE87787 GQ129296 ACT64430 U24166 AAC09471 XM_011528696 XP_011526998 NM_012325 NP_036457 |
Function | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration. {ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404}. |
Subcellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:10644998}. |
EB1 CRISPR/Cas9 KO Plasmid (h) - sc-401367 from Santa Cruz Biotechnology
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EB1 HDR Plasmid (h) - sc-401367-HDR from Santa Cruz Biotechnology
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EB1 Double Nickase Plasmid (h) - sc-401367-NIC from Santa Cruz Biotechnology
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EB1 Double Nickase Plasmid (h2) - sc-401367-NIC-2 from Santa Cruz Biotechnology
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EB1 CRISPR Activation Plasmid (h) - sc-401367-ACT from Santa Cruz Biotechnology
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EB1 CRISPR Activation Plasmid (h2) - sc-401367-ACT-2 from Santa Cruz Biotechnology
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EB1 Lentiviral Activation Particles (h) - sc-401367-LAC from Santa Cruz Biotechnology
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EB1 Lentiviral Activation Particles (h2) - sc-401367-LAC-2 from Santa Cruz Biotechnology
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EB1 siRNA (h) - sc-35258 from Santa Cruz Biotechnology
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EB1 shRNA Plasmid (h) - sc-35258-SH from Santa Cruz Biotechnology
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EB1 shRNA (h) Lentiviral Particles - sc-35258-V from Santa Cruz Biotechnology
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MAPRE1 RNAi - H00022919-R01 from Novus Biologicals
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MISSION® esiRNA - EHU045671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13025 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13025 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09961 from Sigma-Aldrich
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MAPRE1 siRNA (Human) - CRH7872 from Cohesion Biosciences
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shRNA set against Human MAPRE1 (NM_012325.2) - SHH338195 from Creative biogene
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Human MAPRE1 siRNA - orb268374 from Biorbyt
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MAPRE1 shRNA Plasmid (Human) - CHH7872 from Cohesion Biosciences
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MAPRE1 miRNA 3'UTR clone - MiUTR3H-05678 from Creative biogene
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