FADS2

Gene Symbol FADS2
Entrez Gene 9415
Alt Symbol D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13
Species Human
Gene Type protein-coding
Description fatty acid desaturase 2
Other Description delta(6) desaturase|delta(6) fatty acid desaturase|delta-6 desaturase|delta-6 fatty acid desaturase|delta-6-desaturase|linoleoyl-CoA desaturase (delta-6-desaturase)-like 2
Swissprots A8K2M6 Q9H3G3 O95864 B7Z634 Q6MZQ7 Q96SV8 Q96H07 Q9Y3X4
Accessions CAF86135 EAW73974 EAW73975 O95864 AA665550 AF084559 AAG23121 AF108658 AAG43192 AF126799 AAD20018 AK027459 BAG51327 AK027513 BAB55167 AK027577 BAG51351 AK074925 BAG52031 AK074939 BAC11305 AK074991 AK123240 BAG53882 AK290291 BAF82980 AK299762 BAH13120 AL050118 CAB43280 BC009011 AAH09011 DA233832 HY090295 XM_011545395 XP_011543697 NM_001281501 NP_001268430 NM_001281502 NP_001268431 NM_004265 NP_004256
Function Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum. {ECO:0000269|PubMed:12713571, ECO:0000269|PubMed:9867867}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues; lowest levels were found in patients with poor prognostic index. {ECO:0000269|PubMed:10860662, ECO:0000269|PubMed:12851727, ECO:0000269|PubMed:9867867}.
Top Pathways PPAR signaling pathway, alpha-Linolenic acid metabolism, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

FADS2 CRISPR/Cas9 KO Plasmid (h) - sc-402372 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FADS2 HDR Plasmid (h) - sc-402372-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FADS2 Double Nickase Plasmid (h) - sc-402372-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FADS2 Double Nickase Plasmid (h2) - sc-402372-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FADS2 CRISPR Activation Plasmid (h) - sc-402372-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FADS2 CRISPR Activation Plasmid (h2) - sc-402372-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FADS2 Lentiviral Activation Particles (h) - sc-402372-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FADS2 Lentiviral Activation Particles (h2) - sc-402372-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FADS2 siRNA (h) - sc-96449 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FADS2 shRNA Plasmid (h) - sc-96449-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FADS2 shRNA (h) Lentiviral Particles - sc-96449-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU160481 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8091 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8091 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10029 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10029

FADS2 siRNA (Human) - CRH6243 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FADS2 - MBS8205387 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FADS2 (NM_004265.2) - SHH288721 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FADS2(NM_004265.2) - SHH044453 from Creative biogene

Category siRNA
Species Reactivities Human

Human FADS2 siRNA - orb266745 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FADS2 shRNA Plasmid (Human) - CHH6243 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FADS2 miRNA 3'UTR clone - MiUTR1H-03375 from Creative biogene

Species Reactivities Human
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