| Gene Symbol | GSTA4 |
|---|---|
| Entrez Gene | 2941 |
| Alt Symbol | GSTA4-4, GTA4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutathione S-transferase alpha 4 |
| Other Description | GST class-alpha member 4|S-(hydroxyalkyl)glutathione lyase A4|glutathione S-alkyltransferase A4|glutathione S-aralkyltransferase A4|glutathione S-aryltransferase A4|glutathione S-transferase A4|glutathione S-transferase A4-4|glutathione transferase A4-4 |
| Swissprots | Q9H414 O15217 Q9BX18 Q6P4G1 B2RD15 Q5T7Q8 |
| Accessions | AAC72706 AAW56075 EAX04393 EAX04394 EAX04395 EAX04396 EAX04397 EAX04398 EAX04399 O15217 AA709059 AF020918 AAD04711 AF025887 AAC39695 AF125271 AAD27704 AF125272 AAD27705 AF125273 AAD27706 AK054804 BAG51425 AK315369 BAG37762 BC015523 AAH15523 BC063439 AAH63439 BC096817 BG716171 CR749474 CAH18304 DA521337 DQ890661 ABM81587 DQ893841 ABM84767 Y13047 CAA73482 XM_005249035 XP_005249092 XM_011514534 XP_011512836 XM_011514535 XP_011512837 NM_001512 NP_001503 |
| Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE). {ECO:0000269|PubMed:10329152, ECO:0000269|PubMed:20085333}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver. |
| Top Pathways | Chemical carcinogenesis, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450 |