KPNB1

Gene Symbol	KPNB1
Entrez Gene	3837
Alt Symbol	IMB1, IPO1, IPOB, Impnb, NTF97
Species	Human
Gene Type	protein-coding
Description	karyopherin (importin) beta 1
Other Description	PTAC97|importin 1|importin 90|importin beta-1 subunit|importin subunit beta-1|importin-90|karyopherin subunit beta-1|nuclear factor p97|pore targeting complex 97 kDa subunit
Swissprots	Q96J27 Q14637 Q53XN2 D3DTT3 Q14974 B7ZAV6
Accessions	AAA82869 CAM84939 EAW94807 EAW94808 EAW94809 EAW94810 Q14974 AI076614 AK299145 BAH12957 AK301463 BAH13488 AK314780 BAG37316 AK316421 BAH14792 BC003572 AAH03572 BC024045 AAH24045 BC036703 AAH36703 BE046507 BQ009884 BT009797 AAP88799 DB083013 DQ892863 ABM83789 DQ896112 ABM87111 L38951 AAC41763 L39924 NM_001276453 NP_001263382 NM_002265 NP_002256
Function	Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal prot
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11891849}. Nucleus envelope {ECO:0000269|PubMed:11891849}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

D. melanogaster NTF97/Importin beta full length protein - ab90616 from Abcam Category Protein Prices $235.00 Sizes 50 µg Source E. coli Species Drosophila

Human NTF97/Importin beta full length protein - ab116172 from Abcam Category Protein Source E. coli Species Human

Human NTF97/Importin beta peptide - ab50444 from Abcam Category Peptide Species Human

NTF97/Importin beta peptide - ab45936 from Abcam Category Peptide

NTF97/Importin beta peptide - ab45937 from Abcam Category Peptide

KPNB1 / Importin Beta Antibody Blocking Peptide - LS-E22369 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KPNB1 / Importin Beta Antibody Blocking Peptide - LS-E25990 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KPNB1 / Importin Beta Antibody Blocking Peptide - LS-E8481 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Importin beta/KPNB1 Recombinant Protein - H00003837-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Importin beta/KPNB1 Protein - NBP1-78815 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

KPNB1-Antibody-N-term-Blocking-Peptide - BP6816a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SOD2 Protein - GTX116093-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Karyopherin (importin) beta 1 blocking peptide - GTX89314-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Human KPNB1 protein - orb168708 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

KPNB1 Blocking Peptide - 33R-2454 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KPNB1 protein (His tag) - 80R-2058 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

NTF97/importin beta Peptide - AC21-0818-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NTF97 (1-876, His-tag) - AR50141PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

NTF97 (1-876, His-tag) - AR50141PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

NTF97 - H00003837-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NTF97 - H00003837-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

KPNB1, 1-876aa, Human, His tag, E.coli - 01-P1316 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Karyopherin beta 1 Peptide - 45-791P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

KPNB1 fusion protein - Ag0122 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human KPNB1 Protein - BP002683-PRO-1001 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

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