| Gene Symbol | LMAN1 |
|---|---|
| Entrez Gene | 3998 |
| Alt Symbol | ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lectin, mannose-binding, 1 |
| Other Description | ER-Golgi intermediate compartment 53 kDa protein|endoplasmic reticulum-golgi intermediate compartment protein 53|intracellular mannose specific lectin|intracellular mannose-specific lectin MR60|protein ERGIC-53 |
| Swissprots | Q9UQG9 Q9UQG7 Q9UQG8 Q8N5I7 Q9UQH1 Q9UQG4 Q9UQG1 Q9UQH2 Q12895 Q9UQG2 P49257 Q9UQG6 Q9UQG5 Q9UQH0 Q9UQG3 |
| Accessions | AAD32479 AAD32480 AAD32481 AAD32482 AAD32483 AAD32484 AAD32485 AAD32486 AAD32487 AAD32488 AAD32489 AAD32490 EAW63096 EAW63097 EAW63098 P49257 AI280513 AK025773 AK223208 BAD96928 AK225108 AK225111 AK301244 BAG62812 AK312869 BAG35721 BC008401 BC017858 AAH17858 BC032330 AAH32330 DC308886 DQ891254 ABM82180 DQ894440 ABM85366 U09716 AAA95960 X71661 CAA50653 NM_005570 NP_005561 |
| Function | Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. {ECO:0000269|PubMed:12717434, ECO:0000269|PubMed:13130098}. |
| Subcellular Location | Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:13130098}. |
| Top Pathways | Protein processing in endoplasmic reticulum |