| Gene Symbol |
FOXA1
|
| Entrez Gene |
3169
|
| Alt Symbol |
HNF3A, TCF3A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
forkhead box A1
|
| Other Description |
HNF-3-alpha|HNF-3A|TCF-3A|forkhead box protein A1|hepatocyte nuclear factor 3-alpha|transcription factor 3A
|
| Swissprots |
B2R9H6 P55317 B7ZAP5 Q9H2A0
|
| Accessions |
AAD51979 AAG40847 EAW65844 P55317 AK304119 BAG65019 AK313785 BAG36523 AK316360 BAH14731 AM392863 CAL37741 AM393239 CAL38117 AM393310 CAL38188 AM393369 CAL38247 BC033890 AAH33890 BM970983 BU860564 DA705947 U39840 AAB06493 NM_004496 NP_004487
|
| Function |
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activit
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:16331276}.
|
| Tissue Specificity |
Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas. {ECO:0000269|PubMed:12234996, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:16331276}.
|