Gene Symbol | ATP6V0E2 |
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Entrez Gene | 155066 |
Alt Symbol | ATP6V0E2L, C7orf32 |
Species | Human |
Gene Type | protein-coding |
Description | ATPase, H+ transporting V0 subunit e2 |
Other Description | H+-ATPase e2 subunit|V-ATPase subunit e 2|V-type proton ATPase subunit e 2|lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2|vacuolar proton pump subunit e 2|vacuolar proton-ATPase subunit |
Swissprots | Q7Z4R7 Q6MZW1 Q8N7I8 A2T8L7 A2T863 J3KQW7 B5MDP5 Q8NHE4 Q75L47 |
Accessions | AAQ96859 EAW80020 EAW80021 EAW80022 EAW80023 Q8NHE4 AA912295 AF452639 AAP97693 AK057700 AK094602 AK098362 BAC05292 AK172725 AK290086 BAF82775 AY037164 AAK67647 BC015899 BE677432 BX640846 CAE45916 DB544557 DQ989009 ABK88279 DQ995344 ABK76305 NM_001100592 NP_001094062 NM_001289990 NP_001276919 NM_145230 NP_660265 NR_110612 |
Function | Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Isoform 1 is expressed at high levels in heart, brain and kidney and also detected in inner ear epithelium, vestibule, testis, epididymis and bladder. Isoform 2 is expressed in heart, kidney, placenta and pancreas. Isoform 2 is not detected in frontal cortex, but is prevalent in all other brain areas. {ECO:0000269|PubMed:17350184}. |
Top Pathways | Epithelial cell signaling in Helicobacter pylori infection, Vibrio cholerae infection, Collecting duct acid secretion, Phagosome, Rheumatoid arthritis |
ATP6V0E2 CRISPR/Cas9 KO Plasmid (h) - sc-414760 from Santa Cruz Biotechnology
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ATP6V0E2 HDR Plasmid (h) - sc-414760-HDR from Santa Cruz Biotechnology
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ATP6V0E2 Double Nickase Plasmid (h) - sc-414760-NIC from Santa Cruz Biotechnology
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ATP6V0E2 Double Nickase Plasmid (h2) - sc-414760-NIC-2 from Santa Cruz Biotechnology
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V-ATPase E2 CRISPR Activation Plasmid (h) - sc-414760-ACT from Santa Cruz Biotechnology
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ATP6V0E2 CRISPR Activation Plasmid (h2) - sc-414760-ACT-2 from Santa Cruz Biotechnology
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ATP6V0E2 Lentiviral Activation Particles (h) - sc-414760-LAC from Santa Cruz Biotechnology
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ATP6V0E2 Lentiviral Activation Particles (h2) - sc-414760-LAC-2 from Santa Cruz Biotechnology
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ATP6V0E2 siRNA (h) - sc-89474 from Santa Cruz Biotechnology
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ATP6V0E2 shRNA Plasmid (h) - sc-89474-SH from Santa Cruz Biotechnology
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ATP6V0E2 shRNA (h) Lentiviral Particles - sc-89474-V from Santa Cruz Biotechnology
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ATP6V0E2 RNAi - H00155066-R01 from Novus Biologicals
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MISSION® esiRNA - EHU083771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3725 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3725 from Sigma-Aldrich
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ATP6V0E2 siRNA (Human) - CRJ5813 from Cohesion Biosciences
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ATP6V0E2 - MBS8211659 from MyBioSource
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shRNA set against Human Atp6v0e (NM_145230.2) - SHH243062 from Creative biogene
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shRNA set against Human ATP6V0E2(NM_145230.2) - SHG083557 from Creative biogene
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Human ATP6V0E2 siRNA - orb276314 from Biorbyt
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ATP6V0E2 shRNA Plasmid (Human) - CHJ5813 from Cohesion Biosciences
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ATP6V0E2 miRNA 3'UTR clone - MiUTR1H-00714 from Creative biogene
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ATP6V0E2 miRNA 3'UTR clone - MiUTR3H-11614 from Creative biogene
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