| Gene Symbol | CBC2 |
|---|---|
| Entrez Gene | 855925 |
| Alt Symbol | CBP20, MUD13, SAE1 |
| Species | Yeast |
| Gene Type | protein-coding |
| Description | Cbc2p |
| Other Description | - |
| Swissprots | D6W3J0 Q08920 |
| Accessions | DAA11256 Q08920 NM_001183992 NP_015147 |
| Function | Component of the CBC complex, which binds co- transcriptionally to the cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV. {ECO:0000269|PubMed:10490594, ECO:0000269|PubMed:10823828, ECO:0000269|PubMed:12756324, ECO:0000269|PubMed:14671320, ECO:0000269|PubMed:15753296, ECO:0000269|PubMed:16166263, ECO:0000269|PubMed:8682299, ECO:0000269|PubMed:8811086, ECO:0000269|PubMed:8858145, ECO:0000269|PubMed:9215889}. |
| Subcellular Location | Nucleus. Cytoplasm, perinuclear region. Note=Predominantly nuclear, is able to exit the nucleus in an RNA- dependent manner. |
| Top Pathways | Spliceosome, RNA transport, mRNA surveillance pathway |
AOS1+UBA2 protein - Chemical Free - ab80763 from Abcam
|
||||||||||
Recombinant Saccharomyces cerevisiae Nuclear cap-binding protein subunit 2(CBC2) - CSB-YP600152SVG CSB-EP600152SVG CSB-BP600152SVG CSB-MP600152SVG from Cusabio
|
||||||||||
Nuclear cap-binding protein subunit 2 (CBC2), Recombinant Protein - MBS1328889 from MyBioSource
|
||||||||||