DACT1

Gene Symbol	DACT1
Entrez Gene	51339
Alt Symbol	DAPPER, DAPPER1, DPR1, FRODO, HDPR1, THYEX3
Species	Human
Gene Type	protein-coding
Description	dishevelled-binding antagonist of beta-catenin 1
Other Description	dapper antagonist of catenin 1|dapper homolog 1|dapper, antagonist of beta-catenin, homolog 1|hepatocellular carcinoma novel gene 3 protein|heptacellular carcinoma novel gene 3
Swissprots	Q86TY0 A8MYJ2 Q9NYF0
Accessions	EAW80742 Q9NYF0 AF251079 AAF65569 AI803159 AK299879 BAH13159 AK316164 BAH14535 AK316169 BAH14540 AK316237 BAH14608 AK316423 BAH14794 AY603415 AAT99436 BC172261 AAI72261 BC172563 AAI72563 BK000256 DAA00310 BU742074 BX161433 CAD61905 CN304224 DR001289 DR157190 XM_006720167 XP_006720230 NM_001079520 NP_001072988 NM_016651 NP_057735 NR_046093 NR_046095
Function	Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome- dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway
Subcellular Location	Cytoplasm. Nucleus. Cell junction, synapse {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Dact1 / Dapper homolog 1 peptide - ab42546 from Abcam Category Peptide

Human Dact1 / Dapper homolog 1 peptide - ab23139 from Abcam Category Peptide Species Human

Human Dact1 / Dapper homolog 1 protein fragment - ab153345 from Abcam Category Protein Source Wheat germ Species Human

Mouse Dact1 / Dapper homolog 1 peptide - ab42379 from Abcam Category Peptide

DACT1 / DAPPER Antibody Blocking Peptide - LS-E8044 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DACT1 / DAPPER Antibody Blocking Peptide - LS-E22906 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DACT1 / DAPPER Antibody Blocking Peptide - LS-E23030 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DACT1 / DAPPER Antibody Blocking Peptide - LS-E23029 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Dact1 Protein - H00051339-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DACT1-Antibody-N-term-Blocking-peptide - BP5921a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DACT1 - H00051339-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DACT1 - H00051339-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Recombinant Human Dapper homolog 1(DACT1) ,partial - CSB-YP873691HU CSB-EP873691HU CSB-BP873691HU CSB-MP873691HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Dact1 Recombinant Protein Antigen - NBP1-85308PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DACT1 Peptide, Human - M34GP04010H from Creative Peptides Category Peptide Source Synthetic. Species Human

Dapper homolog 1 (DACT1), partial, Recombinant Protein - MBS1286152 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

DACT1 fusion protein - Ag26096 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

DACT1 fusion protein - Ag26110 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Recombinant Human DACT1 Protein, GST-tagged - DACT1-2322H from Creative Biomart Category Protein Source Wheat Germ Species Human

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