| Gene Symbol |
shd
|
| Entrez Gene |
39592
|
| Alt Symbol |
314a1, CG13478, CYP314A1, Cyp314a1, Dmel\CG13478, cyp314a1
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
shade
|
| Other Description |
CG13478-PB|CG13478-PC|CG13478-PD|cytochrome P450|ecdysone 20-monooxygenase|shd-PB|shd-PC|shd-PD
|
| Swissprots |
Q8T483 Q9VUF8
|
| Accessions |
AAF49727 AAS65010 AGB94536 Q9VUF8 AY089309 AAL90047 NM_001274914 NP_001261843 NM_140452 NP_648709 NM_206352 NP_996074
|
| Function |
Required for CNS development; midline glial cells. Involved in the metabolism of insect hormones; responsible for all ecdysone 20-monooxygenase activity during embryonic, larval and adult stages. May be involved in the breakdown of synthetic insecticides. {ECO:0000269|PubMed:12676319, ECO:0000269|PubMed:14610274}.
|
| Subcellular Location |
Mitochondrion membrane {ECO:0000269|PubMed:14610274}.
|
| Tissue Specificity |
Strong expression by embryonic stage 10 in epidermis, decreases significantly in older embryos. Third instar larvae show expression in the midgut copper cells, Malpighian tubules and fat body. In the adult ovaries, expression is seen in both nurse cells and centripetally migrating follicle cells. {ECO:0000269|PubMed:14610274}.
|
| Top Pathways |
Insect hormone biosynthesis
|