DIAPH1

Gene Symbol DIAPH1
Entrez Gene 1729
Alt Symbol DFNA1, DIA1, DRF1, LFHL1, hDIA1
Species Human
Gene Type protein-coding
Description diaphanous-related formin 1
Other Description diaphanous homolog 1|diaphanous-related formin-1|protein diaphanous homolog 1
Swissprots Q59FH8 B7ZKW2 O60610 Q17RN4 A6NF18 Q9UC76 E9PEZ2
Accessions EAW61919 EAW61920 O60610 AB209482 BAD92719 AF051782 AAC05373 AK023345 BAB14533 AK057994 AK094264 AK301195 BAG62775 AK304291 BAG65149 AK307822 AL050086 AY007129 AY360322 AAQ64023 AY363395 AAQ63049 BC007411 AAH07411 BC117257 AAI17258 BC143413 AAI43414 BC143414 BQ945734 BT007318 AAP35982 DA593734 DQ067452 AAZ23039 DQ067453 AAZ23040 XM_005268384 XP_005268441 XM_011537572 XP_011535874 XM_011537573 XP_011535875 NM_001079812 NP_001073280 NM_005219 NP_005210
Function Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membr
Subcellular Location Cell membrane. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Note=Membrane ruffles, especially at the tip of ruffles, of motile cells.
Tissue Specificity Expressed in brain, heart, placenta, lung, kidney, pancreas, liver, skeletal muscle and cochlea.
Top Pathways Focal adhesion, Regulation of actin cytoskeleton

DIAPH1 293T Cell Transient Overexpression Lysate(Denatured) - H00001729-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

DIAPH1 overexpression lysate - LY421547 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

DIAPH1 293 Cell Lysate - 409536 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg
Species Drosophila

DIAPH1 Overexpression Lysate (Denatured) - H00001729-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
DIAPH1 transfected lysate

DIAPH1 Overexpression Lysate (Native) - NBP2-08476 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: DIAPH1 Overexpression Lysate (Adult Normal) [NBP2-08476] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DIAPH1.

DIAPH1 Overexpression Lysate (Native) - NBP2-07773 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg

DIAPH1 Over-expression Lysate Product - GWB-5B5EE0 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

DIAPH1 Overexpression Lysate (Native) - NBP2-09814 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: DIAPH1 Overexpression Lysate (Adult Normal) [NBP2-09814] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DIAPH1.

DIAPH1 Overexpression Lysate (Denatured) - H00001729-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human DIAPH1 Knockdown Stable Cell Line - CSC-DC004301 from Creative biogene

Category Cell Line
Species Human

Human DIAPH1 Knockout Cell Line-HEK293T - CSC-RT0977 from Creative biogene

Category Cell Line
Species Human

DIAPH1 KO Cell Lysate-HEK293T - CLKO-0468 from Creative biogene

Category Cell Lysate
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