| Gene Symbol |
Patj
|
| Entrez Gene |
44100
|
| Alt Symbol |
BcDNA:LD22238, CG12021, D-Patj, DLT, DPATJ, DPatj, Dlt, Dmel\CG12021, Dpatj, PATJ, PaTJ, PatJ, Patj/Dlt, dPATJ, dPatj, dlt, dlt:discs lost, dpatj, patj
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
CG12021 gene product from transcript CG12021-RC
|
| Other Description |
CG12021-PA|CG12021-PB|CG12021-PC|Patj-PA|Patj-PB|Patj-PC|discs lost|discslost|patj
|
| Swissprots |
Q9NB04 Q9XZ35 Q9UA56
|
| Accessions |
AAF47573 AAG22224 AAN11498 Q9NB04 AF132193 AAD34781 NM_057994 NP_477342 NM_134317 NP_599144 NM_167917 NP_728674
|
| Function |
Involved in cell polarity establishment. Probably participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. {ECO:0000269|PubMed:14667407}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:10102271, ECO:0000269|PubMed:11076972}. Note=Membrane-associated. Localizes to the subapical domain of cells. Sdt is required for its localization. At mitotic cycles 13 and 14, during cellularization, it localizes at the leading edge of the invaginating membranes. It is then exclusively localized to the basal area of columnal epithelial cells. In the germline, it localizes at the membrane of the nurse cells during early and mid oogenesis. Later, it is found in the nuclear membrane in close association with actin filaments that connect the nuclei of the nurse cells with the plasma membrane.
|
| Tissue Specificity |
Expressed in primary and some secondary epithelial cells such as ectodermal cells, salivary glands, foregut, hindgut and invaginating tracheal cells. Also expressed in specific cells of the peripheral nervous system. Expressed in the germline. {ECO:0000269|PubMed:10102271, ECO:0000269|PubMed:11076972}.
|
| Top Pathways |
Hippo signaling pathway - fly
|