| Gene Symbol |
Cttn
|
| Entrez Gene |
13043
|
| Alt Symbol |
1110020L01Rik, Ems1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
cortactin
|
| Other Description |
mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)|src substrate cortactin
|
| Swissprots |
Q3UGC2 Q60598
|
| Accessions |
EDL18246 EDL18247 EDL18248 EDL18249 EDL18250 EDL18251 Q60598 AK003869 AK084249 BAC39148 AK146856 BAE27485 AK148010 BAE28287 AK165555 BAE38252 AK168699 BAE40543 AK168871 AK168945 BAE40752 AK177866 AK178661 AK180662 AK183339 AK184325 AK184845 AK185163 AK187968 AK189485 AK192685 AK195592 AK196419 AK196614 AK197295 AK197563 AK197846 AK202001 AK203816 AK206447 AK207194 AK216063 AK216633 AK218098 AK219085 BC011434 AAH11434 BC117820 BY137811 BY265697 BY760295 U03184 AAA19689 XM_006508473 XP_006508536 XM_006508474 XP_006508537 XM_006508475 XP_006508538 XM_011241978 XP_011240280 NM_001252572 NP_001239501 NM_007803 NP_031829
|
| Function |
Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:17403031). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (PubMed:22262902). Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1- phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-c
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection {ECO:0000250|UniProtKB:Q66HL2}. Cell projection, podosome {ECO:0000250|UniProtKB:Q01406}. Cell projection, dendritic spine {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:Q66HL2}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction {ECO:0000250|UniProtKB:Q66HL2}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q66HL2}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q66HL2}. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers. In the presence of CTTNBP2, localizes at the cell cortex. In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft. Colocalizes with DNM2 at the basis of filopodia
|
| Tissue Specificity |
Expressed in most tissues, except in B- lymphocytes or plasma cells.
|
| Top Pathways |
Tight junction, Bacterial invasion of epithelial cells, Proteoglycans in cancer
|