| Gene Symbol |
TRIP13
|
| Entrez Gene |
9319
|
| Alt Symbol |
16E1BP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thyroid hormone receptor interactor 13
|
| Other Description |
16E1-BP|HPV16 E1 protein binding protein|HPV16 E1 protein-binding protein|TR-interacting protein 13|TRIP-13|human papillomavirus type 16 E1 protein-binding protein|pachytene checkpoint protein 2 homolog|thyroid receptor interacting protein 13|thyroid receptor-interacting protein 13
|
| Swissprots |
D3DTC0 O15324 Q15645 C9K0T3
|
| Accessions |
EAX08185 EAX08186 Q15645 AK310376 BC000404 AAH00404 BC019294 AAH19294 BG722761 BM999741 CR456744 CAG33025 DB443523 EU446745 ABZ92274 L40384 AAC41732 U96131 AAB64095 XM_011514163 XP_011512465 NM_001166260 NP_001159732 NM_004237 NP_004228
|
| Function |
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). {ECO:0000250}.
|