| Gene Symbol |
MAP3K5
|
| Entrez Gene |
4217
|
| Alt Symbol |
ASK1, MAPKKK5, MEKK5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase 5
|
| Other Description |
ASK-1|MAP/ERK kinase kinase 5|MAPK/ERK kinase kinase 5|MEK kinase 5|MEKK 5|apoptosis signal regulating kinase 1|apoptosis signal-regulating kinase 1
|
| Swissprots |
B4DGB2 Q5THN3 Q99683 A6NIA0 Q99461
|
| Accessions |
AAT52164 EAW47942 Q99683 AB209093 BAD92330 AK293953 BAG57328 AK294507 BAG57723 AK310942 BC054503 AAH54503 BC088829 AAH88829 D84476 BAA12684 U67156 AAC50894 XM_011535837 XP_011534139 XM_011535838 XP_011534140 XM_011535839 XP_011534141 NM_005923 NP_005914
|
| Function |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7
|
| Subcellular Location |
Cytoplasm. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
|
| Tissue Specificity |
Abundantly expressed in heart and pancreas.
|
| Top Pathways |
Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway, Neurotrophin signaling pathway, Protein processing in endoplasmic reticulum, TNF signaling pathway
|
![Western Blot: ASK1 Overexpression Lysate (Adult Normal) [NBL1-12856] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ASK1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7803_ASK1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12856-img0002.jpg)