| Gene Symbol |
NOX5
|
| Entrez Gene |
79400
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NADPH oxidase, EF-hand calcium binding domain 5
|
| Other Description |
NADPH oxidase 5
|
| Swissprots |
Q9HAM8 Q08AN2 Q96PH2 Q96PH1 Q9H6E0 Q96PJ9 B2RBJ4 Q08AN3 Q8TEQ1 Q96PJ8 Q8TER4
|
| Accessions |
ABC40743 Q96PH1 AF317889 AAG33638 AF325189 AAK57193 AF325190 AAK57194 AF353088 AAK57338 AF353089 AAK57339 AI091544 AK026011 BAB15319 AK074058 BAB84884 AK074071 BAB84897 AK314689 BAG37241 AY166601 AAO33926 BC125097 AAI25098 BC125098 AAI25099 DA739867 DA868876 DQ413001 ABD92513 NM_001184779 NP_001171708 NM_001184780 NP_001171709 NM_024505 NP_078781 NR_033671 NR_033672
|
| Function |
Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. {ECO:0000269|PubMed:11483596, ECO:0000269|PubMed:12686516, ECO:0000269|PubMed:17275676}.
|
| Subcellular Location |
Isoform v5: Endoplasmic reticulum.
|
| Tissue Specificity |
Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level). {ECO:0000269|PubMed:11376945, ECO:0000269|PubMed:11483596, ECO:0000269|PubMed:12686516, ECO:0000269|PubMed:16179589, ECO:0000269|PubMed:16339585, ECO:0000269|PubMed:17275676}.
|