Gene Symbol | SI |
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Entrez Gene | 6476 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | sucrase-isomaltase (alpha-glucosidase) |
Other Description | oligosaccharide alpha-1,6-glucosidase|sucrase-isomaltase, intestinal |
Swissprots | Q1RMC2 P14410 A2RUC3 Q1JQ80 |
Accessions | EAW78601 P14410 AA376756 BC115033 BC115034 AAI15035 BC116452 AAI16453 BC116453 BC132834 AAI32835 BC132860 AAI32861 BG187733 DA919374 M22616 AAA60551 X63597 CAA45140 XM_011513078 XP_011511380 NM_001041 NP_001032 |
Function | Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides. {ECO:0000269|PubMed:20356844}. |
Subcellular Location | Apical cell membrane; Single-pass type II membrane protein. Note=Brush border. |
Tissue Specificity | Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon. {ECO:0000269|PubMed:1677636}. |
Top Pathways | Carbohydrate digestion and absorption, Galactose metabolism, Starch and sucrose metabolism |
Sucrase-Isomaltase CRISPR/Cas9 KO Plasmid (h) - sc-401348 from Santa Cruz Biotechnology
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Sucrase-Isomaltase HDR Plasmid (h) - sc-401348-HDR from Santa Cruz Biotechnology
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Sucrase-Isomaltase Double Nickase Plasmid (h) - sc-401348-NIC from Santa Cruz Biotechnology
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Sucrase-Isomaltase Double Nickase Plasmid (h2) - sc-401348-NIC-2 from Santa Cruz Biotechnology
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Sucrase-Isomaltase CRISPR Activation Plasmid (h) - sc-401348-ACT from Santa Cruz Biotechnology
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Sucrase-Isomaltase CRISPR Activation Plasmid (h2) - sc-401348-ACT-2 from Santa Cruz Biotechnology
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Sucrase-Isomaltase Lentiviral Activation Particles (h) - sc-401348-LAC from Santa Cruz Biotechnology
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Sucrase-Isomaltase Lentiviral Activation Particles (h2) - sc-401348-LAC-2 from Santa Cruz Biotechnology
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Sucrase-Isomaltase siRNA (h) - sc-72188 from Santa Cruz Biotechnology
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Sucrase-Isomaltase shRNA Plasmid (h) - sc-72188-SH from Santa Cruz Biotechnology
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Sucrase-Isomaltase shRNA (h) Lentiviral Particles - sc-72188-V from Santa Cruz Biotechnology
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SI Sucrase-Isomaltase RNAi - H00006476-R01 from Novus Biologicals
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MISSION® esiRNA - EHU017221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1886 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1886 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05066 from Sigma-Aldrich
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SI siRNA (Human) - CRH4377 from Cohesion Biosciences
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SI - MBS8205004 from MyBioSource
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SI shRNA Plasmid (Human) - CHH4377 from Cohesion Biosciences
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SI miRNA 3'UTR clone - MiUTR3H-10835 from Creative biogene
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