TOP3A

Gene Symbol	TOP3A
Entrez Gene	7156
Alt Symbol	TOP3, ZGRF7
Species	Human
Gene Type	protein-coding
Description	topoisomerase (DNA) III alpha
Other Description	DNA topoisomerase 3-alpha|DNA topoisomerase III alpha|topo III-alpha|zinc finger, GRF-type containing 7
Swissprots	Q13472 Q13473 A8KA61 D3DXC7 B4DK80
Accessions	ADP90454 ADP90455 ADP90456 ADP90457 ADP90458 ADP90459 ADP90460 ADP90461 ADP90462 ADP90463 ADP90464 ADP90465 ADP90466 ADP90467 ADP90468 ADP90469 ADP90470 ADP90471 ADP90472 ADP90473 ADP90474 ADP90475 ADP90476 ADP90477 ADP90478 ADP90479 ADP90480 ADP90481 ADP90482 ADP90483 ADP90484 ADP90485 ADP90486 ADP90487 ADP90488 ADP90489 ADP90490 ADP90491 ADP90492 ADP90493 EAW55646 EAW55647 EAW55648 EAW55649 Q13472 AF086042 AK126869 BAG54385 AK290513 BAF83202 AK292926 BAF85615 AK296437 BAG59092 AK299764 BAG61652 AK311668 BC051748 AAH51748 BM462184 U43431 AAB03694 XM_005256776 XP_005256833 XM_011524000 XP_011522302 XM_011524001 XP_011522303 NM_004618 NP_004609
Function	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity. {ECO:0000269|PubMed:20445207, ECO:0000269|PubMed:8622991}.
Tissue Specificity	High expression is found in testis, heart, skeletal muscle and pancreas.
Top Pathways	Homologous recombination, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TOP3A ELISA Kit (Sandwich ELISA) - LS-F8268 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.156-10 ng/ml

Topoisomerase III (TOP3), Human, ELISA Kit - SED800Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.053ng/mL Range 0.156-10ng/mL

topoisomerase (DNA) III alpha, ELISA Kit - MBS9318137 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Topoisomerase III (TOP3) - SED800Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Topoisomerase III (TOP3) - SED800Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Topoisomerase III (TOP3), Human, ELISA Kit - DL-TOP3-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human TOP3 ELISA Kit - abx571371 from Abbexa Category ELISA Kit Sensitivity 0.053 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human TOP3A ELISA Kit - E038598 from Biobool Category ELISA Kit

Human TOP3 ELISA Kit - E038607 from Biobool Category ELISA Kit Sensitivity Typically less than 0.053ng/mL.

TOP3A ELISA Kit (Human) (OKCD00409) - OKCD00409 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.053 ng/mL Range 0.156-10 ng/mL

TOP3 ELISA Kit (Human) (OKDD00571) - OKDD00571 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.053 ng/mL Range 0.156-10 ng/mL

Human DNA topoisomerase 3-alpha (TOP3A) ELISA Kit - AE13790HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.053 ng/mL Range 0.156-10 ng/mL

Topoisomerase III (TOP3), ELISA Kit - MBS454503 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.053ng/mL Range 0.156-10ng/mL

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