| Gene Symbol |
Ogt
|
| Entrez Gene |
108155
|
| Alt Symbol |
1110038P24Rik, 4831420N21Rik, AI115525, Ogtl
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
|
| Other Description |
O-GlcNAc transferase subunit p110|O-linked N-acetylglucosamine transferase 110 kDa subunit|UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
|
| Swissprots |
Q8CGY8 Q6PG10 A2ALY1 Q8BXH6 Q91Y38
|
| Accessions |
AAO17363 EDL14137 EDL14138 Q8CGY8 AF363030 AAK39123 AK041765 AK045910 AK047095 BAC32961 AK075653 AK076418 BAC36331 AK088505 AK149194 AK163296 BAE37282 AK165328 BC021889 BC025097 BC037194 AAH37194 BC038435 BC048239 BC055851 AAH55851 BC057319 AAH57319 BY196484 CB236717 CB520299 CD544482 CF166269 XM_006527736 XP_006527799 XM_011247503 XP_011245805 NM_001290535 NP_001277464 NM_139144 NP_631883
|
| Function |
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediat
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1. After insulin induction, translocated from the nucleus to the cell membrane via phophatidylinisotide binding. Colocalizes with AKT1 at the plasma membrane (By similarity). {ECO:0000250}.
|
| Top Pathways |
Other types of O-glycan biosynthesis
|
