TIMP1

Gene Symbol	TIMP1
Entrez Gene	7076
Alt Symbol	CLGI, EPA, EPO, HCI, TIMP
Species	Human
Gene Type	protein-coding
Description	TIMP metallopeptidase inhibitor 1
Other Description	TIMP-1|collagenase inhibitor|erythroid potentiating activity|erythroid-potentiating activity|fibroblast collagenase inhibitor|metalloproteinase inhibitor 1|tissue inhibitor of metalloproteinases 1
Swissprots	P01033 Q9UCU1 Q14252
Accessions	AAA75558 AAX47478 BAA01913 CAR95107 CAS92765 CBX47572 EAW59315 EAW59316 P01033 A10416 CAA00898 AK074854 BAG52016 AK296116 BAG58865 AK307222 AK310206 AK311937 BAG34878 BC000866 AAH00866 BC007097 BQ181804 BU857950 CR407638 CAG28566 CR541982 CAG46779 DQ891122 ABM82048 DQ894301 ABM85227 M12670 AAA52436 M59906 AAA63234 S68252 AAD14009 X02598 CAA26443 X03124 CAA26902 XM_005272645 XP_005272702 NM_003254 NP_003245
Function	Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. {ECO:0000269|PubMed:1420137, ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:17050530, ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:20545310, ECO:0000269|PubMed:22427646, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540, ECO:0000269|PubMed:8576151, ECO:0000269|P
Subcellular Location	Secreted {ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3010309, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540}.
Tissue Specificity	Detected in rheumatoid synovial fluid (at protein level). {ECO:0000269|PubMed:1730286}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TIMP1 full length protein - ab82104 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Human

Active human TIMP1 full length protein - ab155705 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source HEK 293 cells Species Human

Active human TIMP1 full length protein - ab134456 from Abcam Category Protein Prices $755.00 Sizes 50 µl Species Human

Human TIMP1 full length protein - ab92963 from Abcam Category Protein Source E. coli Species Human

Human TIMP1 full length protein - ab157282 from Abcam Category Protein Source Native Species Human

Human TIMP1 full length protein - ab151942 from Abcam Category Protein Source HEK 293 cells Species Human

Human TIMP1 full length protein - ab39313 from Abcam Category Protein Source Native Species Human

Human TIMP1 full length protein - ab55236 from Abcam Category Protein Source E. coli Species Human

Human TIMP1 full length protein - ab195100 from Abcam Category Protein Source Mammalian Species Human

Human TIMP1 full length protein - ab202236 from Abcam Category Protein Source Insect cells Species Human

TIMP1 peptide - ab41144 from Abcam Category Peptide

TIMP1 peptide - ab41145 from Abcam Category Peptide

TIMP1 peptide - ab41148 from Abcam Category Peptide

TIMP1 peptide - ab86650 from Abcam Category Peptide

TIMP1 Antibody Blocking Peptide - LS-E831 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TIMP1 Antibody Blocking Peptide - LS-E27793 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TIMP1 Antibody Blocking Peptide - LS-E8402 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TIMP-1 Recombinant Protein - H00007076-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TIMP-1 Human Expressed Protein - NBP1-99910 from Novus Biologicals Category Protein Prices $265.00 Sizes 5 µg Source Human neutrophil granulocytes (Buffy Coat) Species Human

Recombinant Human TIMP-1 Protein - NBP1-99909 from Novus Biologicals Category Protein Prices $265.00 Sizes 5 µg Source Sf9 cells Species Human

TIMP1-Antibody-C-term-Blocking-peptide - BP11199b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TIMP1-Antibody-N-term-Blocking-Peptide - BP6709a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TIMP1 Recombinant Protein (Active) - GTX48124-PRO from GeneTex Category Protein Prices $329.00 Sizes 10 μg Source E. coli Species Human

Recombinant Human TIMP-1, CF - 970-TM-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Cys24-Ala207

Recombinant Mouse TIMP-1 Western Blot Standard Protein - WBC022 from R&D Systems Category Protein Prices $109.00 Sizes 1 vial Species Mouse

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