| Gene Symbol |
CLCN2
|
| Entrez Gene |
1181
|
| Alt Symbol |
CIC-2, CLC2, ECA2, ECA3, EGI11, EGI3, EGMA, EJM6, EJM8, LKPAT, clC-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chloride channel, voltage-sensitive 2
|
| Other Description |
chloride channel 2|chloride channel protein 2
|
| Swissprots |
B4DQT9 Q6IPA9 O14864 Q8WU13 B4DZ58 P51788 E9PCD2 E9PBD9
|
| Accessions |
AAB34722 EAW78248 EAW78249 EAW78250 P51788 AA524434 AF026004 AAB88807 AK298952 BAG61051 AK302389 BAG63705 AK302759 BAG63970 AU132760 BC021578 AAH21578 BC072004 AAH72004 BX089717 DB533341 DC403930 XM_006713489 XP_006713552 XM_006713490 XP_006713553 XM_011512401 XP_011510703 XM_011512402 XP_011510704 NM_001171087 NP_001164558 NM_001171088 NP_001164559 NM_001171089 NP_001164560 NM_004366 NP_004357
|
| Function |
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. {ECO:0000269|PubMed:19153159, ECO:0000269|PubMed:19191339}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Ubiquitously expressed. Moderately expressed in aortic and coronary vascular smooth muscle cells and expressed at a low level in aortic endothelial cells. {ECO:0000269|PubMed:10198195}.
|
| Top Pathways |
Mineral absorption
|
![Western Blot: CLCN2 Overexpression Lysate (Adult Normal) [NBL1-09233] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CLCN2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/7982_CLCN2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09233-img0002.jpg)