| Gene Symbol | CLCN2 |
|---|---|
| Entrez Gene | 1181 |
| Alt Symbol | CIC-2, CLC2, ECA2, ECA3, EGI11, EGI3, EGMA, EJM6, EJM8, LKPAT, clC-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chloride channel, voltage-sensitive 2 |
| Other Description | chloride channel 2|chloride channel protein 2 |
| Swissprots | B4DQT9 Q6IPA9 O14864 Q8WU13 B4DZ58 P51788 E9PCD2 E9PBD9 |
| Accessions | AAB34722 EAW78248 EAW78249 EAW78250 P51788 AA524434 AF026004 AAB88807 AK298952 BAG61051 AK302389 BAG63705 AK302759 BAG63970 AU132760 BC021578 AAH21578 BC072004 AAH72004 BX089717 DB533341 DC403930 XM_006713489 XP_006713552 XM_006713490 XP_006713553 XM_011512401 XP_011510703 XM_011512402 XP_011510704 NM_001171087 NP_001164558 NM_001171088 NP_001164559 NM_001171089 NP_001164560 NM_004366 NP_004357 |
| Function | Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. {ECO:0000269|PubMed:19153159, ECO:0000269|PubMed:19191339}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Ubiquitously expressed. Moderately expressed in aortic and coronary vascular smooth muscle cells and expressed at a low level in aortic endothelial cells. {ECO:0000269|PubMed:10198195}. |
| Top Pathways | Mineral absorption |