CDK2

Gene Symbol	CDK2
Entrez Gene	1017
Alt Symbol	CDKN2, p33(CDK2)
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 2
Other Description	cdc2-related protein kinase|cell division protein kinase 2|p33 protein kinase
Swissprots	O75100 P24941 A8K7C6
Accessions	AAM34794 EAW96856 EAW96857 EAW96858 EAW96859 EAW96860 P24941 AA789250 AA810989 AB012305 BAA32794 AK291941 BAF84630 AK293246 BAG56780 AM393136 CAL38014 BC003065 AAH03065 BJ991087 BT006821 AAP35467 DA814453 DQ890598 ABM92215 DQ893767 ABM84693 M68520 AAA35667 X61622 CAA43807 X62071 CAA43985 XM_011537732 XP_011536034 NM_001290230 NP_001277159 NM_001798 NP_001789 NM_052827 NP_439892
Function	Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).
Top Pathways	Oocyte meiosis, Cell cycle, Measles, Herpes simplex infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® CDK2 siRNA II - 7417 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® CDK2 siRNA I - 8618 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Cdk2 CRISPR/Cas9 KO Plasmid (h) - sc-400111 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cdk2 HDR Plasmid (h) - sc-400111-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cdk2 Double Nickase Plasmid (h) - sc-400111-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cdk2 Double Nickase Plasmid (h2) - sc-400111-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cdk2 CRISPR Activation Plasmid (h) - sc-400111-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cdk2 CRISPR Activation Plasmid (h2) - sc-400111-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cdk2 Lentiviral Activation Particles (h) - sc-400111-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cdk2 Lentiviral Activation Particles (h2) - sc-400111-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cdk2 siRNA (h) - sc-29259 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cdk2 shRNA Plasmid (h) - sc-29259-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cdk2 shRNA (h) Lentiviral Particles - sc-29259-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cdk2 siRNA (h2) - sc-156139 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cdk2 shRNA Plasmid (h2) - sc-156139-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cdk2 shRNA (h2) Lentiviral Particles - sc-156139-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CDK2 RNAi - H00001017-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CDK2 RNAi - H00001017-R03 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

CDK2 RNAi - H00001017-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU061761 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0344 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0346 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0345 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1571 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1571 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

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