CSE1L

Gene Symbol	CSE1L
Entrez Gene	1434
Alt Symbol	CAS, CSE1, XPO2
Species	Human
Gene Type	protein-coding
Description	CSE1 chromosome segregation 1-like (yeast)
Other Description	cellular apoptosis susceptibility protein|chromosome segregation 1-like protein|exp2|exportin-2|importin-alpha re-exporter
Swissprots	Q9NTS0 F8W904 B2R5T4 A3RLL6 Q9UPA0 P55060 Q9UP98 E1P5Y0 O75432 Q9H5B7 Q9UP99 Q32M40
Accessions	AAC35297 EAW75676 EAW75677 P55060 AF053640 AAC35007 AF053641 AAC35008 AF053642 AAC35009 AI018123 AI973168 AK098618 AK225610 AK297270 BAG59743 AK297314 BAG59779 AK298477 BAG60688 AK299549 BAG61494 AK300589 BAG62287 AK307965 AK312306 BAG35231 BC108309 AAI08310 BC109313 AAI09314 BC109314 AAI09315 BG392946 DC402014 EF426455 ABO15009 EU832780 ACE87791 GQ129319 ACT64453 U33286 AAC50367 XM_011528599 XP_011526901 NM_001256135 NP_001243064 NM_001316 NP_001307 NR_045796 NM_177436
Function	Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:9323134}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Tissue Specificity	Highly expressed in proliferating cells.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cellular Apoptosis Susceptibility full length protein - ab114716 from Abcam Category Protein Source Wheat germ Species Human

Human Cellular Apoptosis Susceptibility protein fragment - ab114717 from Abcam Category Protein Source Wheat germ Species Human

CSE1L Antibody Blocking Peptide - LS-E10611 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CSE1L/CAS/Exportin-2 Recombinant Protein - H00001434-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CSE1L/CAS/Exportin-2 Protein - H00001434-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CSE1L Blocking Peptide - 33R-2571 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XPO2 Blocking Peptide - abx062471 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog

XPO2 / Exportin-2 - H00001434-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

XPO2 / Exportin-2 - H00001434-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

XPO2 / Exportin-2 - H00001434-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

XPO2 / Exportin-2 - H00001434-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CSE1L fusion protein - ag17556 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CSE1L - CSE1L-27394TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CSE1L - CSE1L-27953TH from Creative Biomart Category Protein Source Wheat germ

XPO2 Blocking Peptide - CBP1277 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Chicken, Dog

CSE1L (E2) Peptide - BS1080P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) - RPG769Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Pagrus major Exportin-2(cse1l) ,partial - CSB-YP886098EQR CSB-EP886098EQR CSB-BP886098EQR CSB-MP886098EQR from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell

Recombinant Oreochromis niloticus Exportin-2(cse1l) ,partial - CSB-YP804299OET CSB-EP804299OET CSB-BP804299OET CSB-MP804299OET from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell

Recombinant Human Exportin-2(CSE1L) - CSB-YP006042HU CSB-EP006042HU CSB-BP006042HU CSB-MP006042HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

XPO2 / Exportin-2 - TP311478 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CSE1L/CAS/Exportin-2 Recombinant Protein Antigen - NBP2-38384PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CSE1L/CAS/Exportin-2 Recombinant Protein Antigen - NBP2-38383PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Cellular-Apoptosis-Susceptibility-Antibody-N-term-Blocking-peptide - BP1935b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Cellular-Apoptosis-Susceptibility-Antibody-C-term-Blocking-peptide - BP1935a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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