TLR2

Gene Symbol	TLR2
Entrez Gene	7097
Alt Symbol	CD282, TIL4
Species	Human
Gene Type	protein-coding
Description	toll-like receptor 2
Other Description	toll/interleukin 1 receptor-like 4|toll/interleukin-1 receptor-like protein 4
Swissprots	O15454 D1CS49 D1CS45 D1CS48 B3Y612 O60603 Q8NI00
Accessions	ACS88975 ACS88976 ACS88977 ACS88978 ACZ69531 ACZ69532 ACZ69533 ACZ69534 ACZ69535 AFX72318 AFX72319 AFX72320 AFX72321 AFX72322 AFX72323 AFX72324 AFX72325 AFX72326 AFX72327 AFX72328 AFX72329 AFX72330 AFX72331 AFX72332 AFX72333 AFX72334 AFX72335 AFX72336 AFX72337 AFX72338 AFX72339 AFX72340 AFX72341 AFX72342 AFX72343 AFX72344 AFX72345 AFX72346 AFX72347 AFX72348 AFX72349 AFX72350 AFX72351 AFX72352 AFX72353 AFX72354 AFX72355 AFX72356 AFX72357 AFX72358 AFX72359 AFX72360 AFX72361 AFX72362 AFX72363 AFX72364 AFX72365 AFX72366 AFX72367 AFX72368 AFX72369 AFX72370 AFX72371 AFX72372 AFX72373 AFX72374 AFX72375 AFX72376 AFX72377 AFX72378 AFX72379 AFX72380 AFX72381 AFX72382 AFX72383 AFX72384 AFX72385 AFX72386 AFX72387 AFX72388 AFX72389 AFX72390 AFX72391 AFX72392 AFX72393 AFX72394 AFX72395 AFX72396 AFX72397 AFX72398 AFX72399 AFX72400 AFX72401 AFX72402 AFX72403 AFX72404 AFX72405 AFX72406 AFX72407 AFX72408 AFX72409 AFX72410 AFX72411 AFX72412 AFX72413 AFX72414 AFX72415 AFX72416 AFX72417 AFX72418 AFX72419 AFX72420 AFX72421 AFX72422 AFX72423 AFX72424 AFX72425 AFX72426 AFX72427 AFX72428 AFX72429 AFX72430 AFX72431 AFX72432 AFX72433 AFX72434 AFX72435 AFX72436 AFX72437 AFX72438 AFX72439 AFX72440 AFX72441 AFX72442 AFX72443 AFX72444 AFX72445 AFX72446 AFX72447 AFX72448 AFX72449 AFX72450 AFX72451 AFX72452 AFX72453 AFX72454 AFX72455 AFX72456 AFX72457 AFX72458 AFX72459 AFX72460 AFX72461 AFX72462 AFX72463 AFX72464 AFX72465 AFX72466 AFX72467 AFX72468 AFX72469 AFX72470 AFX72471 AFX72472 AFX72473 AFX72474 AFX72475 AFX72476 AFX72477 AFX72478 AFX72479 AFX72480 AFX72481 AFX72482 AFX72483 AFX72484 AFX72485 AFX72486 AFX72487 AFX72488 AFX72489 AFX72490 AFX72491 AFX72492 AFX72493 AFX72494 AFX72495 AFX72496 AFX72497 AFX72498 AFX72499 AFX72500 AFX72501 AFX72502 AFX72503 AFX72504 AFX72505 AFX72506 AFX72507 AFX72508 AFX72509 AFX72510 AFX72511 AFX72512 AFX72513 AFX72514 AFX72515 AFX72516 AFX72517 AFX72518 AFX72519 AFX72520 AFX72521 AFX72522 AFX72523 AFX72524 AFX72525 AFX72526 AFX72527 AFX72528 AFX72529 AFX72530 AFX72531 AFX72532 AFX72533 AFX72534 AFX72535 AFX72536 AFX72537 AFX72538 AFX72539 AFX72540 AFX72541 AFX72542 AFX72543 AFX72544 AFX72545 AFX72546 AFX72547 AFX72548 AFX72549 AFX72550 AFX72551 AFX72552 AFX72553 AFX72554 AFX72555 AFX72556 AFX72557 AFX72558 AFX72559 AFX72560 AFX72561 AFX72562 AFX72563 AFX72564 AFX72565 AFX72566 AFX72567 AFX72568 AFX72569 AFX72570 AFX72571 AFX72572 AFX72573 AFX72574 AFX72575 AFX72576 AFX72577 AFX72578 AFX72579 AFX72580 AFX72581 AFX72582 AFX72583 AFX72584 AFX72585 AFX72586 AFX72587 AFX72588 AFX72589 AFX72590 AFX72591 AFX72592 AFX72593 AFX72594 AFX72595 AFX72596 AFX72597 AFX72598 AFX72599 AFX72600 AFX72601 AFX72602 AFX72603 AFX72604 AFX72605 AFX72606 AFX72607 AFX72608 AFX72609 AFX72610 AFX72611 AFX72612 AFX72613 AFX72614 AFX72615 AFX72616 AFX72617 AFX72618 AFX72619 AFX72620 AFX72621 AFX72622 AFX72623 AFX72624 AFX72625 AFX72626 AFX72627 AFX72628 AFX72629 AFX72630 AFX72631 AFX72632 AFX72633 AFX72634 AFX72635 AFX72636 AFX72637 AFX72638 AFX72639 AFX72640 AFX72641 AFX72642 AFX72643 AFX72644 AFX72645 AFX72646 AFX72647 AFX72648 AFX72649 AFX72650 AFX72651 AFX72652 AFX72653 AFX72654 AFX72655 AFX72656 AFX72657 AFX72658 AFX72659 AFX72660 AFX72661 AFX72662 AFX72663 AFX72664 AFX72665 AFX72666 AFX72667 AFX72668 AFX72669 AFX72670 AFX72671 AFX72672 AFX72673 AFX72674 AFX72675 AFX72676 AFX72677 AFX72678 AFX72679 AFX72680 AFX72681 AFX72682 AFX72683 AFX72684 AFX72685 AFX72686 AFX72687 AFX72688 AFX72689 AFX72690 AFX72691 AFX72692 AFX72693 AFX72694 AFX72695 AFX72696 AFX72697 AFX72698 AFX72699 AFX72700 AFX72701 AFX72702 AFX72703 AFX72704 AFX72705 AFX72706 EAX04952 EAX04953 O60603 AB445624 BAG55021 AF051152 AAC34377 AF424049 AF424050 AF424051 AF424052 AF424053 AF502291 AAM23001 AK125659 BAG54231 AW614989 BC033756 AAH33756 BI769109 DQ012265 AAY85644 DQ012266 AAY85645 DQ012267 AAY85646 DQ012268 AAY85647 DQ012269 AAY85648 DQ012270 AAY85649 DQ012271 AAY85650 DQ894005 ABM84931 EU176198 ABW03649 U88878 AAC34133 XM_005263193 XP_005263250 XM_005263194 XP_005263251 XM_005263195 XP_005263252 XM_005263196 XP_005263253 XM_005263197 XP_005263254 XM_011532215 XP_011530517 XM_011532216 XP_011530518 NM_003264 NP_003255
Function	Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
Subcellular Location	Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
Top Pathways	Herpes simplex infection, Proteoglycans in cancer, Toll-like receptor signaling pathway, Inflammatory bowel disease (IBD), Leishmaniasis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD282 / TLR2 - H00007097-T01 from Acris Antibodies Prices $320.00 Sizes 100 µl

TLR2 293 Cell Lysate - 408787 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

TLR2 Cell Lysate - NBP2-25060 from Novus Biologicals Category Cell Lysate Prices $129.00 Sizes 220 µl

TLR2 Overexpression Lysate (Denatured) - H00007097-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

TLR2 Overexpression Lysate (Native) - NBL1-16952 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Human TLR2 NF-kB/SEAP - (SEAPorter™) Stable Reporter Cell Line - NBP2-26274 from Novus Biologicals Category Cell Line Prices $1,129.00 Sizes 1 vial Species Human

Human TLR2 Stable Cell Line - NBP2-26266 from Novus Biologicals Category Cell Line Prices $849.00 Sizes 1 vial Species Human

TLR2 (h): 293T Lysate - sc-115116 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

TLR2 Over-expression Lysate Product - GWB-C00D21 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Human TLR2 / CD282 (aa 1-587) Insect Cell Lysate (WB positive control) - 10061-H08BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TLR2 / CD282 Insect Cell Lysate (WB positive control) - 10061-H08B1L-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TLR2 (aa 1-587) Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175555 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human TLR2 Baculovirus-Insect cells Transfected Lysate (positive control) (denatured) - orb232798 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human TLR2 Knockdown Stable Cell Line - CSC-DC016001 from Creative biogene Category Cell Line Species Human

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