KLRK1

Gene Symbol	KLRK1
Entrez Gene	22914
Alt Symbol	CD314, D12S2489E, KLR, NKG2-D, NKG2D
Species	Human
Gene Type	protein-coding
Description	killer cell lectin-like receptor subfamily K, member 1
Other Description	NK cell receptor D|NKG2-D type II integral membrane protein|NKG2-D-activating NK receptor
Swissprots	A8K7P4 A8K7K5 Q9NR41 P26718
Accessions	ABF50044 CAA04925 EAW96178 EAW96180 EAW96182 P26718 AF260135 AAF86973 AF260136 AAF86974 AK226161 AK292059 BAF84748 BC039836 AAH39836 CB241686 DA933271 DA960048 NM_007360 NP_031386
Function	Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. {ECO:0000269|PubMed:10426994, ECO:0000269|
Subcellular Location	Cell membrane {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}; Single- pass type II membrane protein {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}. Note=Colocalized with HCST on the cell surface.
Tissue Specificity	Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs). {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:15294961, ECO:0000269|PubMed:16444266}.
Top Pathways	Natural killer cell mediated cytotoxicity, Malaria

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD314 gene - orb91147 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Mouse NKG2D/CD314 (NP_149069) VersaClone cDNA - RDC0851 from R&D Systems Prices $199.00 Sizes 10 µg Species Mouse

Human KLRK1 ORF clone(NM_007360.3) - CDCR006496 from Creative Biomart Species Human Accession NM_007360.3

Human KLRK1 ORF Clone(NM_007360.3) - CDCL168272 from Creative Biomart Species Human Accession NM_007360.3

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone in cloning vector - HG10575-M from Sino Biological Species Human

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10575-NY from Sino Biological Species Human

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10575-CM from Sino Biological Species Human

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10575-CH from Sino Biological Species Human

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10575-ACR from Sino Biological Species Human

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone expression plasmid - HG10575-UT from Sino Biological Species Human

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10575-NH from Sino Biological Species Human

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10575-ACG from Sino Biological Species Human

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10575-NF from Sino Biological Species Human

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10575-CY from Sino Biological Species Human

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10575-NM from Sino Biological Species Human

Human NKG2D/CD314/KLRK1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10575-CF from Sino Biological Species Human

Human KLRK1 / CD314 / NKG2D Gene cDNA Clone (full-length ORF Clone) expression ready, FLAG-tagged - HG10575-M-F from Sino Biological Species Human Accession NM_007360.2

Human KLRK1 ORF clone (NM_007360.3) - CDCL125240 from Creative biogene Species Human

Human KLRK1 ORF clone (NM_007360.2) - CDCB157515 from Creative biogene Species Human

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