| Gene Symbol |
UGT2A2
|
| Entrez Gene |
574537
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 2 family, polypeptide A2
|
| Other Description |
UDP-glucuronosyltransferase 2A2
|
| Swissprots |
J3KNA3 D3GER1 Q9Y4X1 E9PDM7 B4E2F4 D3GER2
|
| Accessions |
FJ664272 ACV70034 FJ664273 ACV70035 NM_001105677 NP_001099147 NM_001301233 NP_001288162
|
| Function |
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium. {ECO:0000269|PubMed:19858781}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Olfactory epithelium and brain. Isoform 2 is mainly expressed in the nasal mucosa. {ECO:0000269|PubMed:10359671, ECO:0000269|PubMed:19858781}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Pentose and glucuronate interconversions, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450
|