BRE

Gene Symbol BRE
Entrez Gene 9577
Alt Symbol BRCC4, BRCC45
Species Human
Gene Type protein-coding
Description brain and reproductive organ-expressed (TNFRSF1A modulator)
Other Description BRCA1-A complex subunit BRE|BRCA1/BRCA2-containing complex subunit 45|BRCA1/BRCA2-containing complex, subunit 4|brain and reproductive organ-expressed protein
Swissprots A8K4X1 D6W563 Q4ZFX8 Q53SD0 D6W562 Q969X9 Q9NXR7 Q13880 Q96P06
Accessions AAX88935 AAY24156 CCQ43945 EAX00542 EAX00543 EAX00544 EAX00545 EAX00546 EAX00547 EAX00548 Q9NXR7 AF015767 AAB69387 AF420602 AAL17814 AF420603 AAL17816 AF420604 AAL17817 AF420605 AAL17818 AK000097 BAA90943 AK098345 AK123076 BAC85532 AK291086 BAF83775 AL566299 AY438031 AAR30499 BC001251 AAH01251 BG422104 BG422293 BI559404 BU172408 CR994399 DQ891264 ABM82190 DQ894451 ABM85377 L38616 AAA64231 NM_001261840 NP_001248769 NM_004899 NP_004890 NM_199191 NP_954661 NM_199192 NP_954662 NM_199193 NP_954663 NM_199194 NP_954664
Function Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptoti
Subcellular Location Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Specificity Expressed in all cell lines examined. Highly expressed in placenta. {ECO:0000269|PubMed:11676476}.

BRE (D8Q1J) Rabbit mAb - 12457 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8Q1J
Western blot analysis of extracts from various cell lines using BRE (D8Q1J) Rabbit mAb.

BRE (A-4) - sc-390368 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BRE (A-4): sc-390368. Western blot analysis of BRE expression in non-transfected: sc-110760 (A) and human BRE transfected: sc-110575 (B) 293 whole cell lysates.

BRE (D-2) - sc-376453 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BRE (D-2): sc-376453. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing cytoplasmic staining of glandular cells.

BRE (C-16) - sc-48847 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BRE (C-16): sc-48847. Western blot analysis of BRE expression in non-transfected: sc-110760 (A) and human BRE transfected: sc-110575 (B) 293 whole cell lysates.

BRE (C-9) - sc-271031 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BRE (C-9): sc-271031. Western blot analysis of BRE expression in non-transfected: sc-110760 (A) and human BRE transfected: sc-110575 (B) 293 whole cell lysates.

BRE (C-20) - sc-48848 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BRE (C-20): sc-48848. Western blot analysis of BRE expression in non-transfected: sc-110760 (A) and human BRE transfected: sc-110575 (B) 293 whole cell lysates.

BRE (H-300) - sc-98896 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
BRE (H-300): sc-98896. Western blot analysis of BRE expression in HeLa (A), Hep G2 (B), NIH/3T3 (C), Raji (D), PC-3 (E) and A-431 (F) whole cell lysates.

BRE (N-12) - sc-48849 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BRE (N-12): sc-48849. Western blot analysis of BRE expression in non-transfected: sc-110760 (A) and human BRE transfected: sc-110575 (B) 293 whole cell lysates.

Anti-BRCC45 antibody - ab192315 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-BRCC45 antibody (ab192315) at 1/1000 dilution + HeLa cell lysate at 35 µgSecondaryGoat anti-rabbit IgG H&L (HRP) at 1/5000 dilution

Anti-BRCC45 antibody - ab67550 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-BRCC45 antibody (ab67550) at 1/500 dilutionLane 1 : BRCC45 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-BRCC45 antibody [EPR11858] - ab177960 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11858
Immunohistochemical analysis of Human pancreas tissue labeling BRCC45 using ab177960 at 1/50 dilution.

Anti-BRCC45 / BRE Antibody - LS-C306567 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-BRCC45 / BRE Antibody (aa325-374) - LS-C291438 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BRCC45 / BRE Antibody (aa51-229) - LS-C186196 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
BRCC45 antibody detects BRE protein at nucleus on Cal27 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded Cal27 xenograft. BRCC45 antibody dilution:1:500.

Anti-BRCC45 / BRE Antibody (C-Terminus) IHC-plus™ - LS-B10354 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-BRCC45 / BRE antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10354 concentration 5 ug/ml.

Anti-BRCC45 / BRE Antibody (N-Terminus) IHC-plus™ - LS-B2700 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-BRE antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2700 concentration 5 ug/ml.

Anti-BRCC45 / BRE Antibody IHC-plus™ - LS-B4837 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-BRE antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4837 concentration 10 ug/ml.

BRE Antibody - NBP1-33038 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: BRE Antibody [NBP1-33038] - A. 30 ug A431 whole cell lysate/extract, B. 30 ug HeLa whole cell lysate/extract 10 % SDS-PAGE gel, antibody dilution 1:1000.

BRE Antibody - NBP1-32304 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: BRE Antibody [NBP1-32304] - (30 ug of whole cell lysate) A:HeLa S3 B:Hep G2 7.5% SDS PAGE diluted at 1:500.

BRE Antibody - NBP1-88359 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BRE Antibody - H00009577-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

BRCC45 Polyclonal Antibody - bs-5710R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BRE antibody produced in rabbit - HPA017926 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-BRE: <B>Cat. No. HPA017926</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney shows strong positivity in tubuli.

Anti-BRCC45 antibody produced in rabbit - SAB3500451 from Sigma-Aldrich

Prices $348.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-BRCC45: <B>Cat. No. SAB3500451</B>: Immunohistochemistry of BRCC45 in human brain tissue with BRCC45 antibody at 2.5 μg/mL.

Anti-BRE antibody produced in rabbit - SAB2702006 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-BRE: <B>Cat. No. SAB2702006</B>: Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using BRE antibody at a 1:200 dilution.
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