RALA

Gene Symbol RALA
Entrez Gene 5898
Alt Symbol RAL
Species Human
Gene Type protein-coding
Description v-ral simian leukemia viral oncogene homolog A (ras related)
Other Description RAS-like protein A|Ras family small GTP binding protein RALA|ras related GTP binding protein A|ras-related protein Ral-A
Swissprots A4D1W3 P11233
Accessions EAL23994 EAW94122 EAW94123 P11233 AF086082 AF493910 AAM12624 AK026850 AK308109 AU132355 BC039858 AAH39858 BM930625 DC313757 M29893 AAA36542 X15014 CAA33118 XM_006715762 XP_006715825 XM_011515466 XP_011513768 XM_011515467 XP_011513769 NM_005402 NP_005393
Function Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. {ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:20005108}.
Subcellular Location Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody.
Top Pathways Pancreatic cancer, Rap1 signaling pathway

v-ral simian leukemia viral oncogene homolog A (ras related) , ELISA Kit - MBS9330319 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ral Activation Assay Kit - 17-300 from EMD Millipore

Category Assay Kit

Custom Human RalA ELISA - ELH-RALA-1 from RayBiotech

Category ELISA Kit
Prices $615.00, $1,107.00, $2,460.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human RalA ELISA Kit - orb384726 from Biorbyt

Category ELISA Kit
Prices $1,411.00, $2,448.00, $5,321.00
Sizes 96 assays, 192 assays, 480 assays

Human RALA ELISA Kit - E095264 from Biobool

Category ELISA Kit

anti-RALA antibody [41D5] - ARG57018 from Arigo Biolaboratories

Category ELISA Kit
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