GPX4

Gene Symbol GPX4
Entrez Gene 2879
Alt Symbol GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx
Species Human
Gene Type protein-coding
Description glutathione peroxidase 4
Other Description phospholipid hydroperoxidase|phospholipid hydroperoxide glutathione peroxidase, mitochondrial|sperm nucleus glutathione peroxidase
Swissprots P36969 O43381 Q9UPK2 Q6PJ59
Accessions AAC03239 AAC28920 AAC32261 AAP72965 EAW69543 EAW69544 EAW69545 EAW69546 P36969 AI274351 AK225859 AL558552 BC010157 AAH10157 BC011836 AAH11836 BC021567 AAH21567 BC022071 AAH22071 BC032695 AAH32695 BC039849 AAH39849 BC046163 AAH46163 BC058329 BI561548 BM764133 BQ648717 CF127510 HY049693 X71973 CAA50793 NM_001039847 NP_001034936 NM_001039848 NP_001034937 NM_002085 NP_002076
Function Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). {ECO:0000250}.
Subcellular Location Isoform Mitochondrial: Mitochondrion.
Tissue Specificity Present primarily in testis.
Top Pathways Glutathione metabolism

GPx-4 CRISPR/Cas9 KO Plasmid (h) - sc-401558 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPx-4 HDR Plasmid (h) - sc-401558-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPx-4 Double Nickase Plasmid (h) - sc-401558-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPx-4 Double Nickase Plasmid (h2) - sc-401558-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPx-4 CRISPR Activation Plasmid (h) - sc-401558-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPx-4 CRISPR Activation Plasmid (h2) - sc-401558-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPx-4 Lentiviral Activation Particles (h) - sc-401558-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPx-4 Lentiviral Activation Particles (h2) - sc-401558-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GPx-4 siRNA (h) - sc-44465 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPx-4 shRNA Plasmid (h) - sc-44465-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPx-4 shRNA (h) Lentiviral Particles - sc-44465-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU119391 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9648 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9648 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00363 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00363

GPX4 siRNA (Human) - CRH1936 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Glutathione Peroxidase 4/GPX4 RNAi - H00002879-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

GPX4 - MBS8224807 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GPX4 shRNA Plasmid (Human) - CHH1936 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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