| Gene Symbol | GPX4 |
|---|---|
| Entrez Gene | 2879 |
| Alt Symbol | GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutathione peroxidase 4 |
| Other Description | phospholipid hydroperoxidase|phospholipid hydroperoxide glutathione peroxidase, mitochondrial|sperm nucleus glutathione peroxidase |
| Swissprots | P36969 O43381 Q9UPK2 Q6PJ59 |
| Accessions | AAC03239 AAC28920 AAC32261 AAP72965 EAW69543 EAW69544 EAW69545 EAW69546 P36969 AI274351 AK225859 AL558552 BC010157 AAH10157 BC011836 AAH11836 BC021567 AAH21567 BC022071 AAH22071 BC032695 AAH32695 BC039849 AAH39849 BC046163 AAH46163 BC058329 BI561548 BM764133 BQ648717 CF127510 HY049693 X71973 CAA50793 NM_001039847 NP_001034936 NM_001039848 NP_001034937 NM_002085 NP_002076 |
| Function | Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). {ECO:0000250}. |
| Subcellular Location | Isoform Mitochondrial: Mitochondrion. |
| Tissue Specificity | Present primarily in testis. |
| Top Pathways | Glutathione metabolism |