HLA-DMA

Gene Symbol HLA-DMA
Entrez Gene 3108
Alt Symbol D6S222E, DMA, HLADM, RING6
Species Human
Gene Type protein-coding
Description major histocompatibility complex, class II, DM alpha
Other Description HLA class II histocompatibility antigen, DM alpha chain|MHC class II antigen DMA|class II histocompatibility antigen, M alpha chain|really interesting new gene 6 protein
Swissprots P28067 Q29639 Q29640
Accessions AAA56993 AAA56994 AHW47929 AHW47946 AHW47963 AHW47980 BAA31432 CAA54169 CAA54170 CAA60781 EAX03658 EAX03659 EAX03660 P28067 AA649861 AK291858 BAF84547 AK298081 BAH12721 AU100342 BC011447 AAH11447 BC026279 AAH26279 CR450324 CAG29320 DQ892839 ABM83765 DQ896086 ABM87085 X62744 CAA44606 NM_006120 NP_006111
Function Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.
Subcellular Location Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
Top Pathways Leishmaniasis, HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection

HLA-DM (MaP.DM1) - sc-32248 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HLA-DM (MaP.DM1) PE: sc-32248 PE. Intracellular FCM analysis of fixed and permeabilized human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

HLA-DMα (E-20) - sc-14532 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

HLA-DMα (H-106) - sc-292171 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

HLA-DMα (I-19) - sc-14536 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

HLA-DMα (NB-B33) - sc-134356 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
HLA-DMα (NB-B33): sc-134356. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human malignant lymphoma, diffuse large B tissue showing membrane localization.

Anti-HLA DM antibody - ab55149 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
HLA DM antibody (ab55149) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human malignant lymphoma, diffuse large B tissue.

Anti-HLA DM antibody - ab96664 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-HLA DM antibody (ab96664) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-HLA DM antibody - ab113870 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HLA DM antibody (ab113870) at 1 µg/ml + MCF7 cell lysate at 10 µg

Anti-HLA DM antibody [TAL 18.1] - ab20170 from Abcam

Prices $359.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone TAL 18.1

Anti-HLA-DMA Antibody (clone 3F12-F11) - LS-C133242 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F12-F11
Immunoperoxidase of monoclonal antibody to HLA-DMA on formalin-fixed paraffin-embedded human malignant lymphoma, diffuse large B tissue. [antibody concentration 3 ug/ml].

Anti-HLA-DMA Antibody (aa52-245) - LS-C186384 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Breast ca using HLA-DMA antibody at 1:250 dilution.

Anti-HLA-DMA Antibody - LS-C155504 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded TUMOR-INFILTRATED LEUKOCYTES, using HLA-DMA antibody at 1:500 dilution.

Anti-HLA-DMA Antibody (clone 3D6) - LS-C142030 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D6

Anti-HLA-DMA Antibody - LS-C311214 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HLA-DMA Antibody - LS-C311215 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HLA-DMA Antibody (aa1-262, Azide-free) - LS-C327576 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-HLA-DMA Antibody (aa58-107) - LS-C135950 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HLA-DMA antibody LS-C135950 Western blot of MCF7 Cell lysate. Antibody concentration 1 ug/ml.

MHC Class II Antibody (CVS20) - NBP2-34848 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone CVS20
Flow Cytometry: MHC Class II Antibody (CVS20) [NBP2-34848] - MHC Class II expression in human PBMCs. Image from verified customer review.

MHC Class II Antibody (M5/114.15.2) - NBP1-43312 from Novus Biologicals

Prices $209.00, $259.00, $329.00
Sizes 50 µg, 100 µg, 500 µg
Host Rat
Clonality Monoclonal
Clone M5/114.15.2
Flow Cytometry: MHC Class II Antibody (M5/114.15.2) [NBP1-43312] - Analysis using the PE conjugate of NBP1-43312. Analysis of mouse splenocyte suspensions using MHC Class II PE and can be used at less than or equal to 0.125 ug per test. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

HLA DMA Antibody (3F12-F11) - H00003108-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F12-F11
Western Blot: HLA DMA Antibody (3F12-F11) [H00003108-M01] - HLA-DMA monoclonal antibody (M01), clone 3F12-F11 Analysis of HLA-DMA expression in U-2 OS.

HLA DMA Antibody - H00003108-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

HLA DMA Antibody - NBP1-85325 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HLA DMA Antibody [NBP1-85325] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

MHC Class II Antibody (M5/114) - NBP2-21789 from Novus Biologicals

Prices $279.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone M5/114

MHC Class II Antibody (vpg3) - NB100-65418 from Novus Biologicals

Prices $299.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone vpg3

MHC Class II Antibody (SPM288) - NBP1-74571 from Novus Biologicals

Prices $309.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone SPM288
Immunohistochemistry-Paraffin: MHC Class II Antibody (SPM288) [NBP1-74571] - Human Tosil tissue stained with Mouse anti MHC II antibody at 1:50 for 30 min @ RT, visualized by using peroxidaseconjugate and AEC chromogen. Note: Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
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