Gene Symbol | C9 |
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Entrez Gene | 735 |
Alt Symbol | ARMD15, C9D |
Species | Human |
Gene Type | protein-coding |
Description | complement component 9 |
Other Description | complement component C9 |
Swissprots | P02748 |
Accessions | AAA51890 CAA69849 CAB66087 EAW55986 EAW55987 EAW55988 P02748 AK308045 BC020721 AAH20721 CB135741 CB157001 DQ891410 ABM82336 K02766 AAA51889 X02176 CAA26117 NM_001737 NP_001728 |
Function | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. |
Subcellular Location | Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore. |
Tissue Specificity | Plasma. |
Top Pathways | Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Amoebiasis |
C9 CRISPR/Cas9 KO Plasmid (h) - sc-401198 from Santa Cruz Biotechnology
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C9 HDR Plasmid (h) - sc-401198-HDR from Santa Cruz Biotechnology
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C9 Double Nickase Plasmid (h) - sc-401198-NIC from Santa Cruz Biotechnology
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C9 Double Nickase Plasmid (h2) - sc-401198-NIC-2 from Santa Cruz Biotechnology
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C9 CRISPR Activation Plasmid (h) - sc-401198-ACT from Santa Cruz Biotechnology
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C9 CRISPR Activation Plasmid (h2) - sc-401198-ACT-2 from Santa Cruz Biotechnology
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C9 Lentiviral Activation Particles (h) - sc-401198-LAC from Santa Cruz Biotechnology
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C9 Lentiviral Activation Particles (h2) - sc-401198-LAC-2 from Santa Cruz Biotechnology
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C9 siRNA (h) - sc-62032 from Santa Cruz Biotechnology
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C9 shRNA Plasmid (h) - sc-62032-SH from Santa Cruz Biotechnology
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C9 shRNA (h) Lentiviral Particles - sc-62032-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU029501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5162 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5162 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02041 from Sigma-Aldrich
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C9 siRNA (Human) - CRH0512 from Cohesion Biosciences
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C9 - MBS8216387 from MyBioSource
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Human C9 siRNA - orb261014 from Biorbyt
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C9 shRNA Plasmid (Human) - CHH0512 from Cohesion Biosciences
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C9 miRNA 3'UTR clone - MiUTR3H-00522 from Creative biogene
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