| Gene Symbol | Mapk8ip3 |
|---|---|
| Entrez Gene | 30957 |
| Alt Symbol | BB120594, D17Wsu15e, JIP-3, JSAP1, JSAP1a, JSAP1b, JSAP1c, JSAP1d, Jip3, Syd2, mKIAA1066 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase 8 interacting protein 3 |
| Other Description | C-Jun-amino-terminal kinase-interacting protein 3|JNK MAP kinase scaffold protein 3|JNK-interacting protein 3|JNK/SAPK-associated protein 1|JNK/SAPK-associated protein 1c|JUN/SAPK-associated protein 1|c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1|mitogen activated protein kinase 8 interacting protein 3|mitogen-activated protein kinase 8-interacting protein 3|sunday driver 2 |
| Swissprots | Q9ESP0 Q9JLH3 Q9JLH2 Q9ESN7 Q9ESN9 Q99KU7 Q9ESN8 Q5D062 Q9R0U7 Q9EQD8 |
| Accessions | AAM45137 AAM45138 BAB16685 EDL22384 EDL22385 EDL22386 EDL22387 EDL22388 EDL22389 Q9ESN9 AB005662 BAA85874 AB043123 BAB16674 AB043124 BAB16675 AB043125 BAB16676 AB093282 BAC41466 AF178636 AAF26842 AF178637 AAF26843 AF262046 AAG36931 AK035619 BAC29126 AK039130 BAC30247 AK043651 AK050770 AK134797 BAE22289 AK163208 AK183706 AK192589 AK216552 BC004003 AAH04003 BC060603 AAH60603 BC065105 AAH65105 BC068312 AAH68312 BM899006 CO433928 NM_001163447 NP_001156919 NM_001163448 NP_001156920 NM_001163449 NP_001156921 NM_001163450 NP_001156922 NM_001163451 NP_001156923 NM_001163453 NP_001156925 NM_013931 NP_038959 |
| Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. {ECO:0000269|PubMed:10523642, ECO:0000269|PubMed:10629060}. |
| Subcellular Location | Cytoplasm. Golgi apparatus. Cytoplasmic vesicle. Cell projection, growth cone. Note=Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells. |
| Tissue Specificity | Highly expressed throughout many regions of the brain and at lower levels in the heart, liver, lung, testes and kidney. All isoforms have been identified in the brain, isoform 1a is also expressed in the spleen and lung. {ECO:0000269|PubMed:10629060, ECO:0000269|PubMed:11024282}. |
| Top Pathways | MAPK signaling pathway |
JIP-3 CRISPR/Cas9 KO Plasmid (m) - sc-424438 from Santa Cruz Biotechnology
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JIP-3 HDR Plasmid (m) - sc-424438-HDR from Santa Cruz Biotechnology
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JIP-3 Double Nickase Plasmid (m) - sc-424438-NIC from Santa Cruz Biotechnology
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JIP-3 Double Nickase Plasmid (m2) - sc-424438-NIC-2 from Santa Cruz Biotechnology
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JIP-3 CRISPR Activation Plasmid (m) - sc-424438-ACT from Santa Cruz Biotechnology
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JIP-3 CRISPR Activation Plasmid (m2) - sc-424438-ACT-2 from Santa Cruz Biotechnology
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JIP-3 Lentiviral Activation Particles (m) - sc-424438-LAC from Santa Cruz Biotechnology
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JIP-3 Lentiviral Activation Particles (m2) - sc-424438-LAC-2 from Santa Cruz Biotechnology
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JIP-3 siRNA (m) - sc-37124 from Santa Cruz Biotechnology
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JIP-3 shRNA Plasmid (m) - sc-37124-SH from Santa Cruz Biotechnology
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JIP-3 shRNA (m) Lentiviral Particles - sc-37124-V from Santa Cruz Biotechnology
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JIP-3 siRNA (m) - sc-43369 from Santa Cruz Biotechnology
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JIP-3 shRNA Plasmid (m) - sc-43369-SH from Santa Cruz Biotechnology
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JIP-3 shRNA (m) Lentiviral Particles - sc-43369-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU066561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN35268 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35268 from Sigma-Aldrich
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MAPK8IP3 siRNA (Mouse) - CRM5094 from Cohesion Biosciences
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shRNA set against Mouse Mapk8ip3 (NM_013931.4) - SHH338115 from Creative biogene
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Mouse MAPK8IP3 siRNA - orb284570 from Biorbyt
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MAPK8IP3 shRNA Plasmid (Mouse) - CHM5094 from Cohesion Biosciences
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