HSPA8

Gene Symbol	HSPA8
Entrez Gene	3312
Alt Symbol	HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
Species	Human
Gene Type	protein-coding
Description	heat shock 70kDa protein 8
Other Description	LPS-associated protein 1|N-myristoyltransferase inhibitor protein 71|constitutive heat shock protein 70|epididymis luminal protein 33|epididymis secretory sperm binding protein Li 72p|heat shock 70kd protein 10|heat shock cognate 71 kDa protein|heat shock cognate protein 54|lipopolysaccharide-associated protein 1
Swissprots	Q9H3R6 P11142
Accessions	CAA68445 EAW67539 EAW67540 EAW67541 EAW67542 P11142 AB034951 BAB18615 AB073886 AF217511 AAF67622 AF352832 AAK17898 AK000571 BAA91262 AK096100 BAG53212 AK129885 AK222628 BAD96348 AK222785 BAD96505 AK292067 BAF84756 AK300404 BAG62134 AK303935 BAG64863 AK310467 BC007276 AAH07276 BC008907 AAH08907 BC015699 AAH15699 BC016179 AAH16179 BC016660 AAH16660 BC019816 AAH19816 BC042163 DC312904 DC395565 DQ891145 ABM82071 DQ894325 ABM85251 EU668349 ACF94502 FJ224294 ACI45986 XM_011542798 XP_011541100 NM_006597 NP_006588 NM_153201 NP_694881
Function	Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:23990462}.
Subcellular Location	Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:11276205}.
Top Pathways	Estrogen signaling pathway, Epstein-Barr virus infection, Legionellosis, Influenza A, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HSPA8 (D12F2) Rabbit mAb - 8444 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D12F2

HSC 70 (B-6) - sc-7298 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

HSC 70 (K-19) - sc-1059 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

HSC 70 (1B5) - sc-59560 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rat Clonality Monoclonal

HSC 70 (6i2) - sc-71270 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rat Clonality Monoclonal

HSP 70/HSC 70 (B-12) - sc-137239 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

HSP 70/HSC 70 (G-1) - sc-137210 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

HSP 70/HSC 70 (H-2) - sc-137211 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

HSP 70/HSC 70 (BRM-22) - sc-59572 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µl ascites Host Mouse Clonality Monoclonal

Anti-Hsc70 antibody - ab98156 from Abcam Prices $384.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Hsc70 antibody [1H3] - ab139304 from Abcam Prices $376.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1H3

Anti-Hsc70 antibody [5B7] - ab69559 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5B7

Anti-Hsc70 antibody [EP1531Y] - ab51052 from Abcam Prices $400.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP1531Y

Anti-HSPA8 / HSC70 Antibody (clone BB70, Atto 390) - LS-C227170 from LifeSpan Bioscience Prices $435.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone BB70

Anti-HSPA8 / HSC70 Antibody (clone BB70, Atto 488) - LS-C227172 from LifeSpan Bioscience Prices $435.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone BB70

Anti-HSPA8 / HSC70 Antibody (clone BB70, Atto 594) - LS-C227177 from LifeSpan Bioscience Prices $435.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone BB70

Anti-HSPA8 / HSC70 Antibody (clone BB70, Atto 565) - LS-C227175 from LifeSpan Bioscience Prices $435.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone BB70

Anti-HSPA8 / HSC70 Antibody - LS-C210651 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-HSPA8 / HSC70 Antibody (clone BB70, Atto 633) - LS-C227178 from LifeSpan Bioscience Prices $435.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone BB70

Anti-HSPA8 / HSC70 Antibody (clone BB70, Atto 700) - LS-C227180 from LifeSpan Bioscience Prices $435.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone BB70

Anti-HSPA8 / HSC70 Antibody (clone BB70, Atto 655) - LS-C227179 from LifeSpan Bioscience Prices $435.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone BB70

Anti-HSPA8 / HSC70 Antibody (clone BB70, Atto 680) - LS-C227181 from LifeSpan Bioscience Prices $435.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone BB70

Anti-HSPA8 / HSC70 Antibody (clone 5G1-95) - LS-C150375 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5G1-95

Anti-HSPA8 / HSC70 Antibody (clone BB70, APC) - LS-C227183 from LifeSpan Bioscience Prices $435.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone BB70

Anti-HSPA8 / HSC70 Antibody (clone BB70, AP) - LS-C227182 from LifeSpan Bioscience Prices $425.00 Sizes 200 µg Host Mouse Clonality Monoclonal Clone BB70

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