Gene Symbol | TMED4 |
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Entrez Gene | 222068 |
Alt Symbol | ERS25, GMP25iso, HNLF, p24alpha3 |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane emp24 protein transport domain containing 4 |
Other Description | endoplasmic reticulum stress-response protein 25 kDa|p24 family protein alpha-3|putative NF-kappa-B-activating protein 156|putative NFkB activating protein HNLF|transmembrane emp24 domain-containing protein 4 |
Swissprots | Q8N2P6 Q7Z432 A4D2K8 Q7Z7H5 B4DFJ4 Q56VW3 |
Accessions | EAL23751 EAW61090 EAW61091 EAW61092 Q7Z7H5 AB097009 BAC77362 AK074557 BAC11058 AK290125 BAF82814 AK294122 BAG57455 AL602839 AM393201 CAL38079 AM393715 CAL38591 AY191223 AAP20105 BC025705 BC035467 BC052641 AAH52641 BC053583 BC057851 AAH57851 BM857430 BP872004 BX461603 BX647965 DA419871 NM_001303058 NP_001289987 NM_001303059 NP_001289988 NM_001303060 NP_001289989 NM_001303061 NP_001289990 NM_001303062 NP_001289991 NM_182547 NP_872353 |
Function | Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
TMED4 CRISPR/Cas9 KO Plasmid (h) - sc-406737 from Santa Cruz Biotechnology
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TMED4 HDR Plasmid (h) - sc-406737-HDR from Santa Cruz Biotechnology
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TMED4 Double Nickase Plasmid (h) - sc-406737-NIC from Santa Cruz Biotechnology
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TMED4 Double Nickase Plasmid (h2) - sc-406737-NIC-2 from Santa Cruz Biotechnology
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TMED4 CRISPR Activation Plasmid (h) - sc-406737-ACT from Santa Cruz Biotechnology
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TMED4 CRISPR Activation Plasmid (h2) - sc-406737-ACT-2 from Santa Cruz Biotechnology
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TMED4 Lentiviral Activation Particles (h) - sc-406737-LAC from Santa Cruz Biotechnology
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TMED4 Lentiviral Activation Particles (h2) - sc-406737-LAC-2 from Santa Cruz Biotechnology
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TMED4 siRNA (h) - sc-89384 from Santa Cruz Biotechnology
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TMED4 shRNA Plasmid (h) - sc-89384-SH from Santa Cruz Biotechnology
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TMED4 shRNA (h) Lentiviral Particles - sc-89384-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU035741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21456 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21456 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12019 from Sigma-Aldrich
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TMED4 siRNA (Human) - CRJ6553 from Cohesion Biosciences
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TMED4 - MBS8220625 from MyBioSource
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TMED4 CRISPR/Cas9 KO Plasmid (h2) - sc-406737-KO-2 from Santa Cruz Biotechnology
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TMED4 HDR Plasmid (h2) - sc-406737-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TMED4 (NM_182547.2) - SHH428608 from Creative biogene
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shRNA set against Human TMED4(NM_182547.2) - SHL075126 from Creative biogene
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Human TMED4 siRNA - orb277054 from Biorbyt
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TMED4 shRNA Plasmid (Human) - CHJ6553 from Cohesion Biosciences
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TMED4 miRNA 3'UTR clone - MiUTR1H-10465 from Creative biogene
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