SLC3A2

Gene Symbol	SLC3A2
Entrez Gene	6520
Alt Symbol	4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
Species	Human
Gene Type	protein-coding
Description	solute carrier family 3 (amino acid transporter heavy chain), member 2
Other Description	4F2 cell-surface antigen heavy chain|CD98 heavy chain|antigen defined by monoclonal antibody 4F2, heavy chain|antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43|lymphocyte activation antigen 4F2 large subunit|monoclonal antibody 44D7|solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2|solute carrier family 3 member 2
Swissprots	P08195 Q13543
Accessions	AAA35489 EAW74118 EAW74119 EAW74120 EAW74121 EAW74122 EAW74123 P08195 AA594112 AB018010 BAA84649 AF055031 AK025584 AK090758 AK094620 AK225304 AK304497 BAG65305 AK304685 BAG65456 AK308797 AK311592 AU143131 BC001061 AAH01061 BC003000 AAH03000 BE018712 BQ128156 BU556953 BX362778 BX443653 CA453972 CB138799 CB151304 CN302816 DC395235 EU832612 ACE87703 EU832683 ACE87015 J02769 AAA51540 J02939 AAA52497 J03569 AAA35536 NM_001012662 NP_001012680 NM_001012664 NP_001012682 NM_001013251 NP_001013269 NM_002394 NP_002385 NR_037193 NM_001012661 NM_001012663
Function	Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocys
Subcellular Location	Apical cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localized to the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the placental apical membrane. Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid- trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1. {ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:3265470, ECO:0000269|PubMed:3480538}.
Top Pathways	Protein digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD98 full length protein - ab131866 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CD98 protein fragment - ab114454 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human CD98 protein fragment - ab152060 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source HEK 293 cells Species Human

Human CD98 protein fragment - ab181902 from Abcam Category Protein Prices $406.00 Sizes 100 µg Source HEK 293 cells Species Human

SLC3A2 / CD98 Heavy Chain Antibody Blocking Peptide - LS-E78 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD98 Recombinant Protein - H00006520-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CD98 Partial Recombinant Protein - H00006520-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SLC3A2-Antibody-C-term-Blocking-peptide - BP10152b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SLC3A2 His tag protein - orb84237 from Biorbyt Category Protein Prices $434.00, $646.00 Sizes 50 μg, 100 μg Source Human Species Human

Human SLC3A2 Protein - abx069130 from Abbexa Category Protein Source E.coli Species Human

Human SLC3A2 Protein - abx069131 from Abbexa Category Protein Source E.coli Species Human

CD98 / SLC3A2 - H00006520-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

CD98 / SLC3A2 - H00006520-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD98 / SLC3A2 - H00006520-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD98 / SLC3A2 - H00006520-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD98 / SLC3A2 - H00006520-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD98, Human, Recombinant - 19-C540 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source HEK293 Species Human

Solute Carrier Family 3, Member 2 (SLC3A2), Human - 20-8910 from ARP American Research Products Category Protein Prices $519.00 Sizes 50 µg Source E.coli Species Human

Solute Carrier Family 3, Member 2 (SLC3A2), Human - 20-8911 from ARP American Research Products Category Protein Prices $519.00 Sizes 50 µg Source E.coli Species Human

SLC3A2 Recombinant Protein - 96-138 from ProSci Category Protein Prices $425.00 Sizes 100 µg Source HEK293 cells Species Human

SLC3A2 fusion protein - Ag7301 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SLC3A2 fusion protein - Ag7280 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CD98 Protein - BP001668-C540 from Syd Labs Category Protein Prices $126.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human SLC3A2, His tagged - SLC3A2-3960H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human SLC3A2 - SLC3A2-26956TH from Creative Biomart Category Protein Source Wheat germ

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